PMID: 8605104Mar 1, 1996Paper

Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder

British Journal of Cancer
S C CliffordJ Lunec

Abstract

Expression of the MRP gene has been demonstrated in vitro to be a casual factor in non-P-glycoprotein-mediated multidrug resistance, and is implicated in resistance to a number of the chemotherapeutic agents currently used in the treatment of high-grade transitional cell carcinoma (TCC) of the bladder (doxorubicin, epirubicin and vinblastine). Using a sensitive RT-PCR-based technique, we have quantified MRP mRNA levels in a series of untreated TCC (n=24), normal bladder (n=5) and control tissue and cell line samples. MRP mRNA was widely expressed and detectable in all samples analysed, with considerable (up to 190-fold) variation observed between individual tumour samples. MRP mRNA levels found in TCC samples were lower than those determined for normal peripheral mononucleocyte (2.3-fold) and testis (4.1-fold) samples, previously reported to be high-expressing tissues, and varied over a similar range to that observed in normal bladder samples. Results indicate that MRP mRNA levels in a greater proportion of high-grade (G3) bladder tumours (55%, 6/11) are significantly reduced (P=0.018) compared with low- and moderate-grade (G1/2) bladder tumours (8%, 1/13), and suggest that MRP mRNA levels frequently become reduced as a consequ...Continue Reading

Citations

Jan 31, 2015·Expert Opinion on Therapeutic Targets·Bishoy M FaltasJonathan E Rosenberg
Nov 17, 2005·Carcinogenesis·R A CrallanJ Southgate
Oct 8, 2003·The Oncologist·Gregory D LeonardSusan E Bates
Feb 10, 2012·Expert Review of Anticancer Therapy·Ross M Drayton, James W F Catto
Sep 24, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Chui-ze KongYan Chen
Aug 29, 2001·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z ChenY Zhang
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K NooterG Stoter
Jul 11, 2003·The Veterinary Clinics of North America. Small Animal Practice·Philip J Bergman

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