PMID: 9529058Apr 7, 1998Paper

Alterations in frequency of interleukin-2 (IL-2)-, gamma interferon-, or IL-4-secreting splenocytes induced by Candida albicans mannan and/or monophosphoryl lipid A

Infection and Immunity
S P LiJ E Domer

Abstract

We have shown previously that intravenous injection of Candida albicans mannan (MAN) into naive mice induced CD8+ effector downregulatory cells and that such cells were not produced if mice were deficient in CD4+ or I-A+ cells during the early interval (< or =30 h) following the introduction of MAN. Moreover, the nonspecific biological response modifier monophosphoryl lipid A (MPL), given in vivo or incubated with cells in vitro, can abrogate the MAN-specific immunomodulatory activity. The mechanism by which the abrogation is mediated is unknown, but it is hypothesized to involve cytokines. Therefore, we measured the number of cytokine-secreting cells for the Thl cytokine interleukin-2 (IL-2) and the Th2 cytokine IL-4, as well as for gamma interferon (IFN-gamma), in splenocyte populations from MAN and/or MPL-treated mice, using an enzyme-linked immunospot assay designed to detect individual cytokine-secreting cells (spot-forming cells [SFC]). Cytokine-secreting cells were demonstrated in cell suspensions enriched for CD4+ cells, but no SFC could be demonstrated in populations enriched for CD8+ cells. Both MAN and MPL, when administered to separate groups of animals, stimulated the production of increased numbers of cytokine-pro...Continue Reading

References

Jul 1, 1992·Immunology Today·M E DorfM Collins
Oct 1, 1991·Immunological Reviews·R L CoffmanR Chatelain
Jan 1, 1990·Cytometry·S MiltenyiA Radbruch
Jan 1, 1990·Infection and Immunity·E BalishT D Oberley
May 1, 1988·Infection and Immunity·P J BakerJ A Rudbach
Dec 1, 1969·Journal of Bacteriology·J Kocourek, C E Ballou
Jun 1, 1967·Journal of Bacteriology·A Restrepo-Moreno, J D Schneidau
Jul 1, 1984·Reviews of Infectious Diseases·E RibiH O Ribi
Jun 1, 1995·European Journal of Immunology·L TonnettiL Romani
Feb 1, 1994·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·G L Gustafson, M J Rhodes
Jun 1, 1994·The Journal of Infectious Diseases·P PuccettiF Bistoni
Nov 1, 1993·Immunology Today·D R Green, D R Webb
Apr 2, 1993·Journal of Immunological Methods·K FujihashiH Kiyono
Jan 1, 1996·Clinical and Experimental Immunology·G L AshersonA Salerno
May 12, 1997·Journal of Immunological Methods·N FavreW Rudin

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Citations

Dec 20, 2000·Antimicrobial Agents and Chemotherapy·A L BaltchL H Bopp
Feb 28, 2002·Oral Microbiology and Immunology·L VitkovW Stoiber
Sep 30, 2017·Cells·Josué da Costa Lima-JuniorFátima Conceição-Silva

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