PMID: 7237513May 1, 1981Paper

Alterations in gastrointestinal steady-state kinetics associated with the growth of experimental tumours

Cell and Tissue Kinetics
C J KovacsD R Burholt

Abstract

Changes in the growth kinetics of the intestinal epithelium were observed in mice bearing the Lewis lung carcinoma and the T1699 mammary adenocarcinoma and in rats bearing the H-4-II-E2 hepatoma. Proliferative activity in the jejunal tissue was markedly depressed with increasing tumour burden. Simultaneously, a significant reduction in total crypt cellularity occurred, followed by a reduction in villus height. While the total number of proliferative cells per crypt decreased, the relative proliferative compartment within the shrinking crypt increased. The rate of mucosal DNA synthesis remained constant during the initial cytokinetic changes, falling only after proliferative activity of the intestine was reduced to less than 50% of control levels. No general correlation could be drawn from the three tumour models studied between the level of gastrointestinal proliferation and tumour size, tumour growth rate or loss of weight by the tumour-bearing animals. However, intestinal proliferation was reduced by 50% when the tumour burden for each of the three tumours reached 6--8% of the host animal weight.

References

Dec 1, 1978·Cancer·E F ClarkeC Waterhouse
Feb 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E R BurnsT H Tsai
Jan 1, 1977·Cell and Tissue Kinetics·R F Hagemann, J J Stragand
Jul 1, 1975·The British Journal of Radiology·R F Hagemann, J P Concannon
Jan 1, 1972·Digestion·T GilatM Loewenthal
Jul 29, 1972·The Medical Journal of Australia
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·A F HopperP A McGovern
Oct 1, 1965·Cancer·R A FischerH M Spiro
Oct 1, 1960·The Journal of Biophysical and Biochemical Cytology·D E WIMBERD R WIMBER
Dec 5, 1964·British Medical Journal·B CREAMER

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Citations

Oct 1, 1981·International Journal of Radiation Oncology, Biology, Physics·C J KovacsD R Burholt

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