Alterations in gene expression of complement components in chronic rhinosinusitis

American Journal of Rhinology & Allergy
Rodney J SchlosserCarl Atkinson

Abstract

The complement cascade forms part of the initial innate response to pathogens in the airway. Complement activation is important in the maintenance of host homeostasis, but excessive and uncontrolled activation may lead to inflammation and disease. The role of the complement pathway in the innate response in chronic rhinosinusitis (CRS) is poorly characterized Methods: Sinus mucosa biopsy specimens from the anterior ethmoid or uncinate process of patients with allergic fungal rhinosinusitis (AFRS), CRS without NPs (CRS-NPs), and controls were harvested and gene and protein expression of C3, factor B (fB), C5, and C7 complement proteins were analyzed using quantitative polymerase chain reaction and immunohistochemical techniques. fB, C3, and C5 gene expression were increased in both AFRS and CRS-NPs compared with controls (p < 0.05). Transcriptional activity for the terminal pathway protein C7 was not significantly increased when compared with controls, with C7 levels actually reduced in AFRS patients when compared with controls. Immunohistochemistry studies showed the presence of C3 and fB on the mucosal surface and in submucosa of both AFRS and CRS-NPs, but not normal controls. Terminal pathway protein C9 was not found in our s...Continue Reading

References

Aug 1, 1987·Clinical Immunology and Immunopathology·R R KewA Janoff
May 1, 1983·Archives of Environmental Health·R PerriconeL Fontana
Aug 1, 1997·The Journal of Allergy and Clinical Immunology·K MaruoH Maeda
May 30, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R OkaK Saijoh
Sep 18, 2002·The Journal of Experimental Medicine·Fernando P PolackRuth A Karron
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Dianne M WaltersMarsha Wills-Karp
Aug 11, 2005·Current Allergy and Asthma Reports·Marsha Wills-Karp, Joerg Koehl
Aug 1, 2006·Molecular Immunology·Bert J C Janssen, Piet Gros
Aug 4, 2006·Molecular Immunology·Fiona C KimberleyB Paul Morgan
Sep 8, 2006·American Journal of Rhinology·Bradford A WoodworthRodney J Schlosser
Oct 17, 2006·The Annals of Otology, Rhinology & Laryngology. Supplement·Rodney J Schlosser
Oct 31, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Molly S BolgerJo Rae Wright
Jun 26, 2007·Cellular Microbiology·Menno van Lookeren CampagneEric J Brown
Sep 18, 2007·Immunologic Research·Pieter-Jan Haas, Jos van Strijp
Sep 26, 2007·Advances in Experimental Medicine and Biology·Peter F ZipfelChristine Skerka
Sep 26, 2007·Advances in Experimental Medicine and Biology·Eckhard R PodackMotoaki Shiratsuchi
Nov 15, 2007·American Journal of Rhinology·Margaret L SkinnerJohn E Baatz
Dec 8, 2007·Nature Reviews. Immunology·Piet GrosBert J C Janssen
Dec 18, 2007·Clinical and Experimental Immunology·C Q SchmidtP N Barlow
Jan 9, 2008·Immunology and Cell Biology·Paul M KnopfAnne S De Groot
Jan 30, 2008·Immunology and Cell Biology·Hyun LeeCharles R Mackay
May 31, 2008·Contributions to Microbiology·Günter RambachCornelia Speth
Aug 19, 2008·Molecular Immunology·Lawrence L K LeungWilliam H Robinson
Oct 14, 2008·Biochemical Pharmacology·P A Ward
Oct 29, 2008·American Journal of Rhinology·Sarah K WiseRodney J Schlosser

❮ Previous
Next ❯

Citations

Dec 21, 2010·Current Allergy and Asthma Reports·Yves LaumonnierJörg Köhl
Dec 12, 2012·Current Allergy and Asthma Reports·Chunwei LiDe-Yun Wang
Mar 3, 2011·Current Infectious Disease Reports·Stella Lee, Andrew P Lane
Jul 14, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kara S DavisCarl Atkinson
Nov 13, 2012·PloS One·Maria Q GaunsbaekSoren Hansen
Feb 9, 2012·Current Allergy and Asthma Reports·Cornelis M van DrunenWytske J Fokkens
Apr 5, 2014·The Journal of Allergy and Clinical Immunology·Jennifer K MulliganRodney J Schlosser
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Dec 3, 2013·The Journal of Allergy and Clinical Immunology·Daniel L Hamilos
Dec 17, 2016·The Journal of Allergy and Clinical Immunology·Griet A Van RoeyBruce K Tan
Jul 27, 2014·The Annals of Otology, Rhinology, and Laryngology·Jeb M JusticeDonald C Lanza
Jan 9, 2013·Journal of Feline Medicine and Surgery·Xiangming GaoSamer Al-Murrani
Mar 7, 2012·American Journal of Rhinology & Allergy·Engin AcıoğluHafize Uzun
Jun 17, 2018·Mucosal Immunology·Jennifer K MulliganCarl Atkinson
Aug 7, 2019·American Journal of Rhinology & Allergy·Michael WynneJennifer K Mulligan
Jul 30, 2020·Journal of Immunology Research·Ulrike WernerBarbara Wollenberg
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Jan 15, 2020·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Feng WangHaihong Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
light microscopy
bronchoalveolar lavage

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.