PMID: 18406679Jan 1, 1995Paper

Alterations in hepatocyte uptake and plasma binding of thyroxine in nonthyroidal illness and caloric deprivation

Trends in Endocrinology and Metabolism : TEM
C F LimG Hennemann

Abstract

Low plasma T(3) in severe illness is widely thought to be due principally to inhibition of 5'-deiodinase activity, but other factors also contribute to this response. Abnormal plasma constituents, namely, 3-carboxy-4-methyl-5-propyl-2-furan propanoic acid (CMPF) and indoxyl sulfate in uremia, and elevated bilirubin and nonesterified fatty acids (NEFA) can impair T(4) transport into hepatocytes, thereby contributing to the lowering of plasma T(3). Assessment of possible endogenous or exogenous inhibitors of T(4) binding to plasma proteins is prone to dilution-dependent artifacts, which can lead to overestimation or underestimation of competitor potency, depending on experimental details. Because the potency of such competitors is a function of their free concentrations in undiluted serum, inhibitory activity may be enhanced by substances that impair their albumin binding. Oleic acid or CMPF can inhibit the effect of drugs such as furosemide or fenclofenac.

References

Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon
Dec 1, 1979·The Journal of Clinical Investigation·A S JenningsR D Utiger
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·C F LimJ R Stockigt
Feb 1, 1990·Endocrine Reviews·R Ekins
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J R StockigtJ Sabto
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·G A Brent, J M Hershman
Nov 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M I SurksL E Shapiro
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·C F LimJ R Stockigt
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·I J ChopraD H Solomon
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·J R StockigtK N Wynne
Oct 21, 1993·The New England Journal of Medicine·S Reichlin
Nov 1, 1993·Metabolism: Clinical and Experimental·C F LimD J Topliss
Jan 1, 1992·Trends in Endocrinology and Metabolism : TEM·T K Wong, J M Hershman

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Citations

Sep 29, 2007·Critical Care Clinics·Olga V Sakharova, Silvio E Inzucchi
Feb 1, 1996·Thyroid : Official Journal of the American Thyroid Association·J W BarlowJ R Stockigt

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