Abstract
A set of well-defined antisera against neuronal and glial proteins were used to characterize patterns of protein expression in rat hippocampus following transection of the fimbira-fornix and perforant pathways or after administration of the selective neurotoxicant trimethyltin (8 mg/kg, i.p.). SNAP-25 (synaptosomal protein, mol. wt 25,000) is a neuron-specific, developmentally regulated presynaptic protein, stannin is a protein enriched in cells sensitive to trimethyltin, and GAP-43 (growth-associated protein, mol. wt 43,000) is associated with axonal growth and regeneration. Glial fibrillary acidic protein is an astrocyte-specific intermediate filament protein and a marker for reactive gliosis. SNAP-25 immunoreactivity was altered following both neurotoxicant and mechanical injury. Three days after fimbria-fornix/perforant path lesions, there was a loss of SNAP-25 immunoreactivity in hippocampal efferent pathways and in the lesioned entorhinal cortex. By day 12, there was evidence of reinnervation of hippocampal subfields by SNAP-25-immunopositive commissural afferent fibers. On day 3, immunoblots showed the appearance of SNAP-25a, a developmental isoform produced by alternative splicing of nine amino acids in exon 5, in lesio...Continue Reading
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Oct 8, 1976·Brain Research·D A MatthewsG Lynch
Jun 25, 1976·Brain Research·G LynchC Cotman
Oct 1, 1992·Neurochemistry International·B EarleyB E Leonard
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·M Aschner, J L Aschner
Jul 1, 1992·Experimental Neurology·J R DayC E Finch
Jan 1, 1990·Neuroscience·J W GeddesM C Wilson
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G A OylerM L Billingsley
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CatsicasM C Wilson
Jun 1, 1985·Journal of Neuroimmunology·L F Eng
Jul 1, 1988·Neuroscience·C D BalabanM L Billingsley
Dec 1, 1989·The Journal of Cell Biology·G A OylerM C Wilson
Jun 1, 1969·Brain Research·G Raisman
Apr 1, 1981·The Journal of Cell Biology·J H Skene, M Willard
Apr 1, 1981·The Journal of Cell Biology·J H Skene, M Willard
Jan 16, 1995·The Journal of Comparative Neurology·P E Schauwecker, T H McNeill
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·I C BarkM C Wilson
Jul 29, 1993·Nature·P De Camilli
Jul 29, 1993·Nature·A Osen-SandS Catsicas
Jan 1, 1993·Annals of Neurology·K A HarrisM L Billingsley
May 28, 1993·Annals of the New York Academy of Sciences·S Barone
Citations
Oct 8, 2004·Schizophrenia Research·S Hossein FatemiIrving I Gottesman
Apr 18, 1998·Brain Research·J NorabergJ Zimmer
Jun 1, 2001·Toxicon : Official Journal of the International Society on Toxinology·C V JurasinskiC L Schengrund
Jun 6, 2000·Journal of Neuroscience Methods·A C ScalletJ C Matthews
Dec 31, 1997·Neurochemistry International·N S DejnekaM L Billingsley
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Jun 2, 1998·Neuroscience·A DugarJ M Lakoski
Aug 6, 1998·Neuroscience·Y W Zhang, M R Del Bigio
May 25, 1999·Neuroscience·E MartíI Ferrer
Jul 3, 1999·Neuroscience·W G HonerA J Dwork
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·U KrügelM Bigl
Jul 8, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D Koczyk, B Oderfeld-Nowak
Jan 30, 2004·Journal of Neurotrauma·Dana L EmeryTracy K McIntosh
Aug 29, 1998·Neuroreport·E Tavares, F J Minano
Jan 6, 1999·Neuroreport·C MalapaniJ Gibbon
Aug 14, 2013·PloS One·Vendula RusnakovaMiroslava Anderova
Jan 24, 2009·Annals of the New York Academy of Sciences·Christina Bark
Feb 11, 2000·Toxicologic Pathology·M A PhilbertK R Reuhl
Jan 29, 2000·Journal of Neuroscience Research·E AnguelovaT Smirnova
Jul 26, 2002·Molecular Psychiatry·S H FatemiP Thuras
Dec 6, 2006·Synapse·Susana R ValdezAlicia M Seltzer
Aug 4, 2009·Hippocampus·Jerome L Rekart, Aryeh Routtenberg
Feb 3, 2006·Journal of Cellular Biochemistry·M L BillingsleyG Veglia
Aug 30, 2014·Behavioural Pharmacology·Francisco Diego Pinheiro FernandesGeanne Matos de Andrade
Apr 25, 2000·Journal of Neurosurgical Anesthesiology·S HimmelseherM Auchter
Jun 30, 2019·Molecular Psychiatry·Vijayasree V GiridharanTatiana Barichello
Nov 6, 2004·The Journal of Biological Chemistry·Malin K Sandberg, Peter Löw
May 26, 2009·Neurotoxicology·Ana-Maria Florea, Dietrich Büsselberg