Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues.

Scientific Reports
Zane StrombergaChristian Moro

Abstract

Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is known to induce significant increases in both the tension and frequency of spontaneous phasic contractions in both urothelium with lamina propria (U&LP) and detrusor muscle via the activation of H1 receptor in juvenile animal models. However, it is unclear whether age affects these contractile responses to histamine. This study assessed the histamine receptor subtypes mediating contraction in juvenile and adult porcine bladders and compared the urothelium with lamina propria and detrusor responses to histamine. Isolated tissue bath studies were conducted using strips of porcine U&LP and detrusor obtained from juvenile (6 months) and adult (3 years) animals exposed to histamine receptor agonists and antagonists. Treatment with histamine (100 µM) in U&LP of juvenile animals caused increases in baseline tension by 47.84 ± 6.52 mN/g (p < 0.001, n = 51) and by 50.76 ± 4.10 mN/g (p < 0.001, n = 55) in adult animals. Furthermore, the frequency of spontaneous phasic contractions was significantly enhanced in response to histamine in U&LP of both juvenile and adult tissues (p < 0.001 for both age groups). Treatment with an H2 agonist in U&LP of...Continue Reading

References

Oct 1, 1977·Urology·O P KhannaR F McMichael
Aug 1, 1992·The Journal of Urology·H LeporE Shapiro
Nov 1, 1991·British Journal of Urology·T J Christmas, J Rode
Aug 7, 1985·European Journal of Pharmacology·M KondoC Tanaka
Jul 1, 1995·Clinical Pharmacology and Therapeutics·G BedaridaB B Hoffman
Jan 1, 1993·Neurourology and Urodynamics·M SaitoR M Levin
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·C FerrettiS Ricci Gamalero
Jan 12, 1999·British Journal of Urology·T Hald, T Horn
Dec 22, 1999·Advances in Experimental Medicine and Biology·E J Macarak, P S Howard
Sep 8, 2000·International Journal of Urology : Official Journal of the Japanese Urological Association·T YamadaK Akiyama
Mar 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Claudia L HofstraWai-Ping Fung-Leung
Jan 20, 2004·Neuroscience Letters·Akira TeraoThomas S Kilduff
Nov 24, 2005·Neurourology and Urodynamics·J J M PelR van Mastrigt
Jan 13, 2006·British Journal of Pharmacology·Mike E Parsons, C Robin Ganellin
Mar 23, 2006·Journal of the American Geriatrics Society·Mathias H-D PfistererNeil M Resnick
Jun 7, 2006·The Journal of Urology·Kirsten Bouchelouche, Pierre Bouchelouche
Jul 12, 2008·BJU International·Ramandeep K BasraCon Kelleher
Sep 29, 2009·International Urology and Nephrology·Pradeep TyagiMichael Chancellor
Jan 21, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JutelC A Akdis
Apr 14, 2011·International Urogynecology Journal·Gamal GhoniemAsim B Abdel-Mageed
Jul 27, 2011·Therapeutic Advances in Urology·Sonal GroverAlexis E Te
Oct 4, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jie ChaoNorberto C Gonzalez
Nov 25, 2011·Respiratory Medicine·Kawa Amin
Nov 29, 2011·European Journal of Pharmacology·Christian MoroRuss Chess-Williams
Oct 22, 2013·The Journal of Urology·Paul W Veenboer, J L H Ruud Bosch
Dec 4, 2013·The Journal of Physiology·Donna M DalyDavid Grundy
Nov 2, 2014·Science·Sarah Harper
Dec 2, 2015·International Neurourology Journal·Tae Young Jang, Young Hyo Kim
Oct 27, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Christian MoroRuss Chess-Williams
May 2, 2018·Pharmacology & Therapeutics·Shizuo YamadaKimio Sugaya
Jul 11, 2018·Asian Journal of Urology·Lori A BirderChristopher R Chapple

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