PMID: 4907839Jan 1, 1970Paper

Alterations in human intestinal microflora during experimental diarrhoea

Gut
S L GorbachG W Hepner

Abstract

Large quantities of fluid administered through an intestinal tube caused alterations in small bowel bacteriology in four of seven subjects. In two normal individuals, colonic bacteria were found after fluid infusion in areas of the small bowel which previously had none. The faecal microflora was also altered by the fluid purge: anaerobes were reduced in some subjects and large numbers of Enterobacter species emerged in others. In a patient with pancreatic insufficiency and diarrhoea, the concentration of Enterobacter in the faeces was directly related to the number of bowel motions per day. Treatment with pancreatic enzymes curtailed the diarrhoea and markedly reduced these organisms. Intubation showed that Enterobacter were harboured in the small intestine and suppressed in the large bowel during periods of normal bowel action. Diarrhoea caused by pancreatic enzyme withdrawal or fluid purgation removed the colonic inhibition and allowed these organisms to appear in the faeces. Acidic diarrhoea induced by lactose feeding to three hypolactasic patients caused reductions in the numbers of E. coli in the stool but increases in Enterobacter species. Bacteroides also declined in one subject. Certain alterations in small and large bo...Continue Reading

References

Aug 1, 1967·The British Journal of Radiology·J W LawsG Neale
Sep 11, 1967·JAMA : the Journal of the American Medical Association·R CohenF Roth
Nov 1, 1963·Annals of Internal Medicine·B H KEAN

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Citations

Sep 1, 1986·Digestive Diseases and Sciences·G L Simon, S L Gorbach
Mar 1, 1971·Diseases of the Colon and Rectum·R L NicholsR E Condon
Feb 1, 1979·The Journal of Hygiene·R B Ellis-PeglerH P Lambert
May 15, 1975·The New England Journal of Medicine·R B SackD A Sack
Apr 2, 2011·Journal of Gastroenterology and Hepatology·Uday C Ghoshal, Prabhat Ranjan
Aug 1, 1973·Australian and New Zealand Journal of Medicine·C B CampbellJ Harper
Mar 1, 1977·Archives of Disease in Childhood·A M KilbyJ A Walker-Smith
Apr 1, 1971·The Journal of Clinical Investigation·S L GorbachR B Sack
Jul 30, 2014·Current Gastroenterology Reports·Brandon Dickinson, Christina M Surawicz
Aug 19, 2010·Journal of Clinical Gastroenterology·Martin J GrehanAntony Wettstein
Jun 1, 1985·The American Journal of the Medical Sciences·J R Mathias, M H Clench
Sep 29, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alan W Walker, Trevor D Lawley
Jul 1, 1985·The Journal of Pathology·M M Mathan, V I Mathan
Sep 22, 2018·Journal of Crohn's & Colitis·Miranda G KiernanColum P Dunne
Sep 14, 1999·The American Journal of Physiology·G Hecht
Jul 13, 2021·AIMS Microbiology·Rayane ChettaouiPatrick Di Martino

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