PMID: 16625700Apr 21, 2006Paper

Alterations in intestinal contractility during inflammation are caused by both smooth muscle damage and specific receptor-mediated mechanisms

Croatian Medical Journal
Adnan TanovićMarcel Jiménez

Abstract

To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model. We examined the changes in worm-positive (jejunum) and worm-free (ileum) intestinal segments of rats infected with T. spiralis. To investigate the relationship between structural and functional changes in smooth muscle, we measured the thickness of the muscle layers of rat jejunum and ileum. Mechanical responses to KCl 30 mmol/L, acetylcholine (ACh) 10(-8)-10(-4) mol/L, substance P (SP) 10(-9)-10(-5) mol/L, and to electrical field stimulation of longitudinal muscle strips in the jejunum and ileum were studied in muscle bath as controls (day 0) and on day 2, 6, 14, 23, and 72 after infection. After T. spiralis infestation, an inflammation of the mucosal and submucosal layers of jejunum was observed, whereas in the worm-free ileum there was not any inflammatory infiltrate. Increase in the smooth muscle thickness of both jejunum and ileum were correlated with increased responses to depolarizing agent KCl and to ACh. However, responses to SP were decreased on day 14-23 after infection in jejunum and from day 6-14 after infection in ileum. Electric field stimulation-induced contractions were transiently decreas...Continue Reading

Related Concepts

Acetylcholine Sulfate (1: 1)
Electric Stimulation Technique
Intestinal Motility
Inflammation
Intestines, Small
Inotropism
Smooth Muscle
Slow-K
Hypothalamic Substance P
Human Trichinellosis

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