Alterations in intestinal microbiota relate to intestinal failure-associated liver disease and central line infections

Journal of Pediatric Surgery
Panliang WangWei Cai

Abstract

The gut microbiota plays a vital role in modulating the metabolic and immune functions of the intestines. We aimed to analyze the dysbiosis of microbiota in infants with short bowel syndrome (SBS) with different complications. We included 26 fecal samples from 18 infants with SBS during parenteral nutrition. The samples were categorized into three groups: asymptomatic, parenteral nutrition-associated liver disease (PNALD), and central line-associated bloodstream infection (CLABSI). Seven healthy infants were enrolled as controls. Fecal microbiota, secretory IgA, calprotectin, bile acids, and short chain fatty acids were detected. The bacterial diversity of the Asymptomatic and Control Groups was significantly higher than that in the PNALD and CLABSI Groups. Proteobacteria was the most pronounced phylum in the PNALD and CLABSI Groups. Decreased acetate was observed in all SBS samples; however, fecal secretory IgA and calprotectin and the proportion of primary and secondary bile acids did not differ from those in healthy controls. Marked alterations of the intestinal microbiota with decreased level of acetate were shown in SBS patients compared with healthy controls. Over-abundance of Proteobacteria (especially Enterobacteriaceae...Continue Reading

Citations

Aug 3, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Esther NeelisKonstantinos Gerasimidis
Sep 22, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Teppei ShimasakiUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Aug 24, 2019·Digestive Diseases and Sciences·Yuhua HuangYousheng Li
May 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jasmeet S MokhaAdam Matson
Jan 16, 2020·Journal of Pediatric Gastroenterology and Nutrition·Suchitra K HouriganSean R Moore
Aug 28, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Jie JiaWei Cai
Jul 3, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Zhicai YuJiang Wu
Feb 1, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Racha T Khalaf, Ronald J Sokol
May 23, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Allison J WuKara L Calkins
Apr 10, 2019·Pediatric Research·Allison F DahlgrenT Hang Nghiem-Rao
Aug 21, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Nandini ChannabasappaHannah Piper
Oct 21, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Saurabh TalathiDavid Galloway
Feb 27, 2021·Journal of Pediatric Gastroenterology and Nutrition·Valeria C Cohran
Aug 2, 2021·Seminars in Perinatology·Rohit Josyabhatla, Essam M Imseis
May 14, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Esther G NeelisKonstantinos Gerasimidis
Oct 31, 2021·Archives of Disease in Childhood·Konstantinos GerasimidisVaios Svolos

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