Alterations in intestinal motility and microflora in experimental acute pancreatitis

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
P LeveauR Andersson

Abstract

A delay in intestinal transit time appears as an early event in acute pancreatitis, preceding intestinal bacterial overgrowth and translocation. Septic complications, primarily caused by bacteria of enteric origin, are frequent in severe acute pancreatitis. Impairment in intestinal motility probably plays a pathophysiological role in the development of bacterial overgrowth and ensuing translocation. In the present study, the influence of acute pancreatitis on intestinal motility was evaluated by measuring small intestinal transit time in the rat. Acute pancreatitis was induced by the retrograde intraductal infusion of 0.2 mL taurodeoxycholate. Intestinal transit time was studied by intraduodenal injection of Krebs' phosphate-buffered solution labeled with Na2(51)CrCO4, and 1 h small intestinal transit was measured at 1, 3, 12, and 24 h, after induction of pancreatitis. Bacterial overgrowth was evaluated by measuring Escherichia coli counts in the colon and distal small intestine, and bacterial translocation to mesenteric lymph nodes, the liver, spleen, and pancreas was determined. A delayed small intestinal transit time was noted from 3 h on after induction of acute pancreatitis, with most of the radioactivity retained in the f...Continue Reading

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Citations

Sep 22, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T C SeerdenB Y De Winter
Jan 12, 2008·World Journal of Gastroenterology : WJG·Wan-Chun WuSheng Li
Sep 2, 2008·Indian Journal of Pediatrics·Sunit C Singhi, A Baranwal
Sep 18, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sunit Singhi
Mar 21, 2009·Current Opinion in Critical Care·Paul E Marik
Oct 5, 2010·Gastroentérologie Clinique Et Biologique·S-M Schneider
Jan 13, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Refaat HegaziStephen J O'Keefe

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