Alterations in Ito1, IKr and Ik1 density in the BIO TO-2 strain of syrian myopathic hamsters

Journal of Molecular and Cellular Cardiology
N J Lodge, D E Normandin

Abstract

The BIO TO-2 strain of cardiomyopathic hamster provides a model of dilated low output heart failure. The goal of the study was to determine whether changes in potassium currents occur in this model of heart failure. The densities of Ito1, IKr and IK1 in 8-month-old myopathic hamsters were not significantly different from their age-matched controls. The half-maximum activation voltage (V1/2) of IKr and Ito1, as well as the voltage-dependence of Ito1 inactivation were also similar in both groups at 8 months. Ito1 inactivation exhibited a double exponential time-course; the slow component (tau2), but not the rapid component (tau1), was larger in the myopathic animals. The densities of Ito1, IKr and IK1 were not significantly different in the 8- and 10-month-old control animals. However, the densities of Ito1, IKr and IK1 were all significantly lower in the 10-month-old myopathic hamsters relative to the 10-month-old controls. The V1/2 for IKr and Ito1 activation was the same in myopathic and control animals. tau2, but not tau1, of Ito1 inactivation was again larger in the myopathic animals. The voltage-dependence of Ito1 inactivation was shifted slightly, but significantly, positive in the myopathic animals. Lastly, a sustained ou...Continue Reading

Citations

Feb 19, 2000·Microscopy Research and Technique·A A HackE M McNally
Sep 25, 2004·Journal of Cellular Physiology·Anthony Collins, Maureen Larson
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Stanley Nattel
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yunlong BaiZhiguo Wang
May 6, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Oana N UrecheGuiscard Seebohm
Oct 3, 2006·Cell Biochemistry and Biophysics·Ilka Lorenzen-SchmidtJeffrey H Omens
Jul 31, 2013·Canadian Journal of Physiology and Pharmacology·Viktoria SzutsNorbert Jost
Apr 28, 1999·FEBS Letters·A SakamotoT Masaki
Jun 23, 2010·Journal of Cellular Physiology·Dana GoldoniAnthony Collins
Oct 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guiscard SeebohmFlorian Lang

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