PMID: 7545762Aug 1, 1995Paper

Alterations in leukocyte adhesion molecule expression after burn injury

The Journal of Trauma
F E NwariakuP E Lipsky

Abstract

To determine if thermal injury alters the expression of leukocyte adhesion molecules. This is a controlled experimental animal study. Partial thickness burns were created on the backs of New Zealand White rabbits. At 30 minutes, 2 hours, 4 hours, and 24 hours after burn, skin was harvested for immunohistochemistry. Monoclonal antibodies were used to study changes in intercellular adhesion molecule 1 (ICAM-1), E-selectin, and leukocyte CD11a. Staining was graded on a scale of 0 to 4. ICAM-1 was significantly decreased at 24 hours after burn (p < 0.007, Wilcoxon signed rank test). CD11a was increased at 30 minutes (p < 0.02), 2 hours (p < 0.02), and 24 hours (p < 0.006). E-selectin was increased at 2 hours (p < 0.03). Thermal injury alters the expression of leukocyte adhesion molecules.

References

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Citations

Mar 20, 2002·Burns : Journal of the International Society for Burn Injuries·Dean E Boyce
Feb 9, 2002·Burns : Journal of the International Society for Burn Injuries·Hiroyuki SakuraiDaniel L Traber
Sep 9, 2000·Forensic Science International : Synergy·J DresslerE Müller
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Freeman SuberFrancis D Moore
May 13, 1998·British Journal of Plastic Surgery·O ShoshaniY Peled
Apr 20, 2006·Burns : Journal of the International Society for Burn Injuries·P Ch FuchsN Pallua
Nov 2, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Hamed SadeghipourCurtis L Cetrulo
Nov 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·George YounanMichael F Gurish

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