Feb 23, 1988

Alterations in local cerebral glucose utilization during electrical stimulation of the striatum and globus pallidus in rats

Brain Research
Y AikoK Kitamura

Abstract

Alterations in local cerebral glucose utilization (LCGU) in conscious rats during electrical stimulation of the striatum and the globus pallidus were investigated using the [14C]deoxyglucose method. Stimulation of the globus pallidus produced a marked contraversive circling behavior, while stimulation of the striatum led only to contraversive head turning. Unilateral stimulation of the striatum increased LCGU bilaterally in the globus pallidus and substantia nigra pars compacta, but only ipsilaterally in the entopeduncular nucleus, substantia nigra pars reticulata and subthalamic nucleus. Similar stimulation of the globus pallidus increased LGCU in the globus pallidus, substantia nigra pars reticulata and compacta, entopeduncular nucleus, subthalamic nucleus, lateral habenular nucleus, parafascicular nucleus of the thalamus, deep layers of the superior colliculus and pedunculopontine nucleus, exclusively on the ipsilateral side. These results indicate that the electrical stimulation induces LCGU changes in the respective structures having both monosynaptic and transsynaptic neuronal inputs. Some changes may also be mediated by antidromic activation. They also suggest that activation of a synaptic process whether excitatory or i...Continue Reading

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Mentioned in this Paper

Pars Compacta
Structure of Endopeduncular Nucleus
Globus Pallidus
Neostriatum
Compacta
Pedunculopontine Tegmental Nucleus
August Rats
Paleostriatum
Brain
Lentiform Nucleus Structure

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