Alterations in membrane fatty acid unsaturation and chain length in hypertension as observed by 1H NMR spectroscopy

American Journal of Hypertension
Y Chi, R K Gupta

Abstract

Alterations in fatty acids of membrane phospholipids in essential hypertension may account for altered membrane ion transport, elasticity, and contractility properties of hypertensive tissues. To investigate the abnormalities in membrane fatty acids in essential hypertension, the degree of fatty acid unsaturation ([-CH=CH-]/[-CH3]), the average carbon chain length, ratio of glycerol to fatty acyl chains, ratio of phosphatidylcholine to fatty acyl chains, and the ratio of free and acylated cholesterol to fatty acyl chains in fatty acid fractions of membrane phospholipids of aorta, kidney, and heart were determined in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats by 1H nuclear magnetic resonance (NMR) spectroscopy. The degrees of fatty acid unsaturation in the aorta and the kidney membranes were significantly lower in SHR than in WKY rats (aorta, 0.53+/-0.01 v 0.63+/-0.01, n = 5, P = .01; kidney, 0.70+/-0.01 v 0.84+/-0.03, n = 10, P = .01). No significant difference could be detected in fatty acid unsaturation in heart membranes between these two strains. For aorta, kidney, and heart membranes, the average carbon chain lengths of fatty acid fractions of membrane phospholipids were significantly shorter for SHR...Continue Reading

Citations

Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·David K W YeungPing C Leung
Sep 14, 2007·Molecular Membrane Biology·Jesús PradesFrancisca Barceló
Feb 16, 2010·Cardiovascular and Interventional Radiology·S MasalaG Simonetti
Jul 18, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kaipin XuXiaojuan Li
Apr 6, 2001·Biotechnology and Bioengineering·A HubelT B Darr

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