PMID: 9420665Sep 1, 1995Paper

Alterations in metabolic clearance of atrial natriuretic peptides in heart failure: how do they relate to the resistance to atrial natriuretic peptides?

Journal of Cardiac Failure
A Clerico, G Iervasi

Abstract

Deficiencies in activity of the atrial natriuretic peptide (ANP) system may be able to explain the disturbed electrolyte and fluid homeostasis occurring in chronic heart failure. Generally, in studies concerning the possible pathophysiologic role of ANP in heart failure, only the circulating levels of the hormone were measured. It has been shown, however, that plasma ANP levels exhibit marked variability attributable to the pulsatory pattern of secretion and to its very short plasma half-life. An evaluation of the main turnover parameters might represent a significant improvement in the assessment of the functioning of the overall ANP system. By using a tracer method, which does not alter the steady-state condition, a disturbed peripheral metabolism of ANP and a resistance to its biologic effects was demonstrated in patients with idiopathic dilated cardiomyopathy, even in those in the asymptomatic phase of the disease, showing ANP circulating levels, atrial pressure and volume, and cardiac index within the normal range. The altered degradation and distribution of ANP in patients with heart failure were demonstrated by a great increase in metabolic clearance (on average, 2.5-fold), production (on average, 6-fold), or both, and b...Continue Reading

References

Aug 15, 1992·The American Journal of Cardiology·D ElsnerG A Riegger
Feb 12, 1994·Lancet·M J Brown
Apr 1, 1994·European Journal of Clinical Investigation·A M NugentD P Nicholls
Oct 1, 1993·Journal of the American College of Cardiology·R R BrandtJ C Burnett

❮ Previous
Next ❯

Citations

Jan 3, 2013·Journal of Paediatrics and Child Health·Alyaa A KotbyHanan S Yosseif
Aug 14, 2012·Biotechnology Journal·Bernard de Bono, Peter Hunter
Mar 11, 2015·European Journal of Heart Failure·John J V McMurray
Mar 11, 1998·Heart & Lung : the Journal of Critical Care·M R PianoD W Schwertz
Dec 31, 2014·Critical Reviews in Clinical Laboratory Sciences·Aldo ClericoClaudio Passino
Oct 30, 2001·The Veterinary Journal·M BorgarelliJ Häggström
Mar 10, 2001·Biological Research for Nursing·S D Kim, M R Piano
Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Aldo ClericoMichele Emdin
Apr 23, 2020·Future Cardiology·Pramod Kumar Kuchulakanti
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·G IervasiL Donato
Aug 20, 2003·European Journal of Clinical Investigation·A CharlouxB Geny

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.