Alterations in mucin expression in ovarian mucinous tumors: immunohistochemical analysis of MUC2, MUC5AC, MUC6, and CD10 expression.

Acta Histochemica Et Cytochemica
Kenichi HirabayashiRobert Yoshiyuki Osamura

Abstract

The aim of this study was to evaluate the immunohistochemical expression of MUC2, MUC5AC, MUC6, and CD10 in ovarian mucinous adenoma (MA), mucinous borderline tumor (MB), and mucinous adenocarcinoma (MC), and to analyze the relationship between prognosis and these expressions. The expression of MUC2, MUC5AC, MUC6, and CD10 was evaluated by immunohistochemical analysis in 29 cases of MA, 29 cases of MB, and 26 cases of MC and scored based on the percentage of positive cells. Moreover, the ovarian mucinous tumors were classified into 4 phenotypes based on the staining patterns: intestinal, gastrointestinal, gastric, and unclassified patterns. The gastrointestinal pattern and the expression of MUC2 and CD10 increased from MA to MC. Conversely, the gastric pattern and MUC5AC expression decreased from MA to MC. Low MUC2 expression in MC was correlated with a better long-term survival rate. MUC2 expression in MC may be a useful predictor of the clinical outcome. The expression patterns of MUC2, MUC5AC, MUC6, and CD10 indicated that intestinal metaplasia may arise from the gastric-like epithelium in MA and that a close association exists between carcinogenesis and intestinal metaplasia in major ovarian mucinous tumors.

References

May 1, 1975·Clinical Immunology and Immunopathology·M F GreavesT A Lister
Jan 1, 1995·Human Reproduction·J P AudieA Boersma
Jan 1, 1995·Annual Review of Physiology·S J Gendler, A P Spicer
Apr 1, 1994·Cancer·D A Bell, R E Scully
Nov 1, 1995·Biochemical Society Transactions·B J Van KlinkenJ Dekker
Oct 1, 1996·Glycoconjugate Journal·Y S KimI Brockhausen
Apr 1, 1997·Biology of Reproduction·I K GipsonJ A Hill
Mar 7, 1998·Journal of Molecular Evolution·J L DesseynA Laine
Jan 10, 1998·The Journal of Pathology·Y DongM A McGuckin
Sep 2, 1998·The International Journal of Biochemistry & Cell Biology·A AllenJ P Pearson
Aug 7, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H WatanabeK Nishikura
Mar 9, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N L HarrisJ Vardiman
Nov 30, 2000·Virchows Archiv : an International Journal of Pathology·L RiethdorfC P Crum
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S TsukashitaT Hattori
Oct 11, 2002·The Journal of Biological Chemistry·Keizou OokawaShigeki Tsuchida
Feb 13, 2003·Japanese Journal of Clinical Oncology·Hong FengTsutomu Araki
Sep 12, 2003·Molecular Phylogenetics and Evolution·Rebecca J Carson, Greg S Spicer
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shumei ZhaoTeiichi Motoyama
Mar 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C WamburaM Kasuga
Jul 27, 2004·American Journal of Clinical Pathology·Sean K LauPeiguo G Chu
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Debra A Bell
Apr 20, 2005·Virchows Archiv : an International Journal of Pathology·Ryoji KushimaManfred Stolte
Jul 27, 2006·Journal of Gastroenterology·Hideki MinematsuYoshihide Fujiyama
Sep 26, 2006·Human Reproduction·Cindy Leigh RussoIlene K Gipson
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·Allyson C BakerDavid Chhieng
Jan 5, 2007·Journal of Gastroenterology and Hepatology·Hiroaki Takeo, Susumu Matsukuma
Sep 18, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E ItoH Makuuchi

❮ Previous
Next ❯

Citations

Oct 10, 2014·Biological Research·Laura García-LabastidaGabriela Gómez-Macías
Aug 3, 2013·Histopathology·Sultan Ahmad HalimiMasashi Fukayama
Nov 26, 2009·Nature Reviews. Cancer·Donald W Kufe
Jul 9, 2020·The Application of Clinical Genetics·Erin L CrowgeyTodd E Druley
Apr 17, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Nicolas JonckheereIsabelle Van Seuningen
Jul 3, 2021·Journal of Personalized Medicine·Ismael Henarejos-CastilloPatricia Diaz-Gimeno

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.