PMID: 2336189Mar 26, 1990Paper

Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviour

Neuroscience Letters
M GautronG Guilbaud


Morphology or peripheral myelinated fibres was analyzed in rats exhibiting hyperalgesia and allodynia with mechanical and thermal stimuli, consecutive to a mononeuropathy induced by 4 loose ligatures around a sciatic nerve. This preliminary study was based on weeks 2-3 after surgery, the time of the maximum alterations of the pain-related behaviour. At this time, contrasting with a marked decrease of the large afferent fibres a consistent number of much less than 5 micron fibres was pointed out. In addition to their extremely short internodal length, the majority of these fibres had an abnormal g-ratio, thus an abnormal myelin sheath. It is suggested that this group of abnormal fibres might be related to the A delta fibres described in neuromas and involved in pain-related behaviours seen in the mononeuropathic rats.


Oct 1, 1993·Muscle & Nerve·G J Bennett
Sep 30, 1991·Neuroscience Letters·S M CarltonR E Coggeshall
Jan 1, 1997·European Journal of Pain : EJP·P ShortlandC Molander
Feb 18, 2014·Neuroscience Research·Kuniaki TsutsumiNobuaki Egashira
Mar 5, 2015·International Journal of Molecular Sciences·Miau-Hwa KoTo-Jung Tseng
May 1, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ilona Klusáková, Petr Dubový
Jan 15, 2005·Neurobiology of Disease·Hou-Yu ChiangSung-Tsang Hsieh
Oct 17, 2006·The European Journal of Neuroscience·Junichi KitagawaKoichi Iwata
Oct 20, 2011·Pharmacology, Biochemistry, and Behavior·Hamid R BanafsheGholam A Hamidi
Sep 19, 2002·Pain·Megumi ShimoyamaNaohito Shimoyama

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