Alterations in myocardial adenylate cyclase in spontaneously hypertensive rats

G C Palmer, S Greenberg


Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, and glucagon. Addition of 5'-guanylylimidodiphosphate to the SHR myocardial preparation again yielded a lessened sensitivity to all agents except norepinephrine, dopamine, and histamine. Chronic treatment of SHR with clonidine and a high dose of propranolol produced a cardiac enzyme that was insensitive to activation by norepinephrine. Similar treatment with a low dose of propranolol did not alter myocardial responses to norepinephrine.


Feb 28, 2004·Trends in Cardiovascular Medicine·R D Feldman, R Gros
Jun 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·S GolfV Hansson
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·H Ikawa, A Suzuki
Aug 1, 1990·Hypertension·M C MichelP A Insel

Related Concepts

Histamine Measurement
Glucagon (rDNA)
Rats, Inbred SHR
Guanylyl Imidodiphosphate
Adrenergic beta-Agonists
Rats, Inbred WKY
Glucagon Measurement

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