Alterations in myocardial adenylate cyclase in spontaneously hypertensive rats

Pharmacology
G C Palmer, S Greenberg

Abstract

Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, and glucagon. Addition of 5'-guanylylimidodiphosphate to the SHR myocardial preparation again yielded a lessened sensitivity to all agents except norepinephrine, dopamine, and histamine. Chronic treatment of SHR with clonidine and a high dose of propranolol produced a cardiac enzyme that was insensitive to activation by norepinephrine. Similar treatment with a low dose of propranolol did not alter myocardial responses to norepinephrine.

References

Feb 28, 2004·Trends in Cardiovascular Medicine·R D Feldman, R Gros
Jun 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·S GolfV Hansson
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·H Ikawa, A Suzuki
Aug 1, 1990·Hypertension·M C MichelP A Insel

Related Concepts

Histamine Measurement
Glucagon (rDNA)
Rats, Inbred SHR
Sultanol
Guanylyl Imidodiphosphate
Myocardium
Adrenergic beta-Agonists
Glucagon
Rats, Inbred WKY
Glucagon Measurement

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