Abstract
Normal aging without disease leads to diminished chronotropic and inotropic responses to catecholamine stimulation, resulting in depressed cardiac function with stress. The purpose of this study was to determine molecular mechanisms for decrements in adrenergic responsiveness of the left ventricle (LV) due to aging and to study the effects of chronic dynamic exercise on signal transduction. We measured beta-adrenergic receptor (beta-AR) density, adenylyl cyclase (AC) activity, and G-protein content and distribution in LV from 66 male Fischer 344 rats from three age groups that were either sedentary or treadmill trained (60 min/days, 5 days/wk, 10 wk at 75% of the maximal capacity). Final ages were 7 mo (young), 15 mo (middle-age), and 25 mo (old). There was no significant difference in beta-AR density among groups as a function of age or training. AC production of adenosine 3',5'-cyclic monophosphate (cAMP) with the use of five pharmacological stimulations revealed that old sedentary myocardium had depressed basal, receptor-dependent, G-protein-dependent, and AC catalyst stimulation (30-43%) compared with hearts from young and middle-age sedentary rats. Training did not alter AC activity in either middle-age or old groups but d...Continue Reading
References
Feb 1, 1975·Circulation Research·E G LakattaM L Weisfeldt
Jan 1, 1992·Circulation·H K HammondC M Bloor
Apr 1, 1991·Journal of Applied Physiology·G PlourdeA Nadeau
Jul 1, 1991·Japanese Circulation Journal·K UrasawaH Yasuda
Jan 13, 1992·FEBS Letters·D A RothH K Hammond
Feb 1, 1992·Circulation·J W FlemingA M Watanabe
Mar 15, 1990·Mechanisms of Ageing and Development·P J Scarpace
May 1, 1989·Metabolism: Clinical and Experimental·R S Mazzeo, P A Grantham
Nov 1, 1988·Journal of the American Geriatrics Society·P J Scarpace
May 12, 1988·Nature·E J Neer, D E Clapham
Dec 1, 1988·Circulation·P A Insel, L A Ransnäs
Jul 1, 1986·Metabolism: Clinical and Experimental·R S MazzeoS M Horvath
Oct 1, 1985·Journal of Applied Physiology·J L FlegE G Lakatta
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell
Mar 29, 1984·The New England Journal of Medicine·R D FeldmanA J Wood
Jun 1, 1982·Mechanisms of Ageing and Development·N Narayanan, J A Derby
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R S MazzeoS M Horvath
May 1, 1995·Progress in Cardiovascular Diseases·R L Moore, D H Korzick
Jan 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M D JohnsonJ Roberts
Aug 1, 1994·Journal of Applied Physiology·P J ScarpaceN Tümer
Apr 1, 1994·Circulation Research·K TobiseC J Homcy
Dec 1, 1993·The Journal of Clinical Investigation·H K HammondP Ping
Mar 1, 1993·The Journal of Clinical Investigation·D A RothH K Hammond
Feb 1, 1993·Circulation·E G Lakatta
Apr 1, 1993·Physiological Reviews·E G Lakatta
Oct 1, 1995·Journal of Molecular and Cellular Cardiology·D A RothW C Stanley
Oct 13, 1995·Mechanisms of Ageing and Development·R S MazzeoV Henry
Jan 1, 1992·Trends in Cardiovascular Medicine·E J Neer, D E Clapham
Citations
Oct 31, 2001·The American Journal of Geriatric Cardiology·J W Weinsaft, J M Edelberg
Apr 2, 2005·Journal of Applied Physiology·Kevin E EklundTimothy I Musch
Jun 24, 2008·Experimental Aging Research·Silvia Del RyEttore Bergamini
Apr 18, 2009·Future Cardiology·James P SticeAnne A Knowlton
Feb 10, 2011·Endocrinology·James P SticeAnne A Knowlton
Oct 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M Harold LaughlinDirk J Duncker
Jun 18, 2002·The Journal of Biological Chemistry·Jason D KiltsMadan M Kwatra
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·D A PodolinD A Roth
Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Dario LeoscoBruno Trimarco
Dec 16, 2003·Journal of Applied Physiology·Tepmanas Bupha-Intr, Jonggonnee Wattanapermpool
Apr 18, 2008·Sports Medicine·Hassane ZouhalArlette Gratas-Delamarche
Mar 16, 2011·European Journal of Applied Physiology·Joseph R Libonati, Scott M MacDonnell
Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Gen TakagiDorothy E Vatner
Mar 1, 2005·Experimental Biology and Medicine·Joan F CarrollAllison M Wright
Aug 18, 2001·Journal of Applied Physiology·F FavretN C Gonzalez
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dario LeoscoFranco Rengo
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Jun 24, 2017·PloS One·Chia-Ying LiuDavid A Bluemke
Nov 24, 2006·American Journal of Therapeutics·Janet Sullivan, Joseph D Tobias
May 20, 2008·Experimental Physiology·Rachel StonesEd White
Aug 19, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James G RyallGordon S Lynch
Oct 8, 2009·Circulation. Cardiovascular Imaging·Susan ChengJoão A C Lima
Nov 4, 2006·Journal of Applied Physiology·Stephen C KolwiczJoseph R Libonati
Oct 25, 2003·Journal of Cardiovascular Pharmacology·Jason D KiltsMadan M Kwatra
Sep 25, 2007·American Journal of Therapeutics·Ehab S ElDesoky
Apr 18, 2001·Brain Research·M SastreJ A García-Sevilla
Dec 10, 2002·Mechanisms of Ageing and Development·Eui-Ju Yeo, Sang Chul Park