Alterations in mystacial pad innervation in the aged rat

Experimental Brain Research
B T FundinB Ulfhake

Abstract

It is well established that sensory perception becomes impaired with advancing age and that, in parallel, dystrophy and degeneration of axons occur in sensory pathways. In this study, the impact of aging was examined in the mystacial pad, which receives a large variety of sensory nerve endings organized in a highly predictable pattern. Mystacial pad specimens from aged (30 months old) and young adult (2-3 months old) female Sprague-Dawley rats were processed, in parallel, for immunohistochemical analyses with antibodies against human neuronal cytoplasmic protein (protein gene product 9.5), transmitter enzymes, and several neuropeptides. Several changes in cutaneous innervation including both degenerative and regenerative processes were evident in the aged rat: (1) the Merkel endings and lanceolate endings that emanate from large-caliber afferents in the whisker follicles were reduced and showed signs of degeneration. Furthermore, a reduction of piloneural complexes at the intervibrissal hairs were evident, but only in aged rats that showed more severe behavioral sensorimotor disturbances. In contrast, Ruffini endings as well as mechanoreceptors emanating from medium-caliber axons, i.e., transverse lanceolate and reticular endin...Continue Reading

Citations

May 21, 2008·Biological cybernetics·Ehud Ahissar, Per Magne Knutsen
Jun 3, 1999·Brain Research. Molecular Brain Research·H JohnsonB Ulfhake
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Jul 25, 2021·Heart Failure Reviews·Hidetaka Hibino, Stacey L Gorniak

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