Alterations in neural systems mediating cognitive flexibility and inhibition in mood disorders

Human Brain Mapping
Camille PiguetPatrik Vuilleumier

Abstract

Impairment in mental flexibility may be a key component contributing to cardinal cognitive symptoms among mood disorders patients, particularly thought control disorders. Impaired ability to switch from one thought to another might reflect difficulties in either generating new mental states, inhibiting previous states, or both. However, the neural underpinnings of impaired cognitive flexibility in mood disorders remain largely unresolved. We compared a group of mood disorders patients (n = 29) and a group of matched healthy subjects (n = 32) on a novel task-switching paradigm involving happy and sad faces, that allowed us to separate generation of a new mental set (Switch Cost) and inhibition of the previous set during switching (Inhibition Cost), using fMRI. Behavioral data showed a larger Switch Cost in patients relative to controls, but the average Inhibition Cost did not differ between groups. At the neural level, a main effect of group was found with stronger activation of the subgenual cingulate cortex in patients. The larger Switch Cost in patients was reflected by a stronger recruitment of brain regions involved in attention and executive control, including the left intraparietal sulcus, precuneus, left inferior fontal ...Continue Reading

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Citations

Apr 9, 2017·Cognitive, Affective & Behavioral Neuroscience·Shaghayegh Konjedi, Reza Maleeh
Jan 15, 2019·International Journal of Bipolar Disorders·Kallia ApazoglouCamille Piguet
Nov 15, 2016·Neuropsychologia·Rebekah L BlakemorePatrik Vuilleumier
Apr 27, 2018·Neuropsychologia·Indrit BèguePatrik Vuilleumier
May 17, 2021·Seminars in Cell & Developmental Biology·Faith M GunningLindsay W Victoria

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