Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis

Journal of Chemical Neuroanatomy
M A Vizzard

Abstract

These studies examined changes in the expression of calcitonin gene-related peptide (CGRP) and substance P (SP) in lumbosacral (L6-S1) micturition reflex pathways, following chronic cystitis induced by cyclophosphamide (CYP). In control Wistar rats, CGRP- or SP-immunoreactivity (IR) was expressed in fibers in the superficial dorsal horn in all segmental levels examined (L4-S1). Bladder afferent cells in the dorsal root ganglia (DRG; L6, S1) from control animals also exhibited CGRP- (41-55%) or SP-IR (2-3%). Following chronic, CYP-induced cystitis, CGRP- and SP-IR were dramatically increased in spinal segments and DRG (L6, S1) involved in micturition reflexes. The density of CGRP- and SP-IR was increased in the superficial laminae (I-II) of the L6 and S1 spinal segments. No changes in CGRP- or SP-IR were observed in the L4-L5 segments. Staining was also dramatically increased in a fiber bundle extending ventrally from Lissauer's tract in lamina I along the lateral edge of the DH to the sacral parasympathetic nucleus in the L6-S1 spinal segments. Following chronic cystitis, CGRP- and SP-IR in cells in the L6 and S1 DRG significantly (P< or =0.05) increased and the percentage of bladder afferent cells expressing CGRP- (76%) or SP-...Continue Reading

References

Mar 1, 1992·Trends in Neurosciences·R Dubner, M A Ruda
Jul 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G Vantini, S D Skaper
May 15, 1992·Journal of the Autonomic Nervous System·C A MaggiS Giuliani
Nov 1, 1991·The Journal of Clinical Investigation·W D SteersJ B Tuttle
Dec 1, 1973·British Journal of Urology·N A Watson, R G Notley
Sep 1, 1983·Brain Research Bulletin·M K DonovanJ M Wyss
Jan 1, 1994·Trends in Neurosciences·T HökfeltZ Wiesenfeld-Hallin
Oct 1, 1994·The Nurse Practitioner·D C Webster, T Brennan
Jun 1, 1995·British Journal of Urology·X PangT C Theoharides
Oct 1, 1994·Journal of the Autonomic Nervous System·J B TuttleE Nataluk
Feb 1, 1995·The Journal of Urology·S A KaplanJ G Blaivas
Jan 1, 1994·The Journal of Comparative Neurology·M A VizzardW C De Groat
Jul 1, 1996·Pain·Natalia Dmitrieva, Stephen B McMahon
May 1, 1997·Neuroscience·N DmitrievaS B McMahon
May 1, 1997·Urology·C A Jones, L Nyberg
Sep 1, 1997·The Journal of Urology·C A Buffington, B E Woodworth
Jul 14, 1997·Journal of the Autonomic Nervous System·P Callsen-Cencic, S Mense
Jan 1, 1997·Urological Research·J Luber-NarodR E Carraway
Jan 29, 2000·The European Journal of Neuroscience·M MalcangioS B McMahon

❮ Previous
Next ❯

Citations

Jun 19, 2008·Journal of Molecular Neuroscience : MN·Simon StudenyMargaret A Vizzard
May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Jun 12, 2003·Autonomic Neuroscience : Basic & Clinical·Haley L BennettJanet R Keast
Feb 16, 2005·The Journal of Urology·Vivian Y HuMargaret A Vizzard
Dec 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birthe SchnegelsbergDebra A Cockayne
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard
Oct 24, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaoyang ZhangPaul C Dolber
Jul 25, 2009·American Journal of Physiology. Renal Physiology·Bopaiah P CheppudiraMargaret A Vizzard
Nov 5, 2010·American Journal of Physiology. Renal Physiology·Beatrice M GirardMargaret A Vizzard
Jun 3, 2011·American Journal of Physiology. Renal Physiology·Lauren Arms, Margaret A Vizzard
Feb 19, 2010·American Journal of Physiology. Renal Physiology·Kimberly CorrowMargaret A Vizzard
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Lauren ArmsMargaret A Vizzard
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Mary Beth Klinger, Margaret A Vizzard
Apr 17, 2014·BioMed Research International·Eric J GonzalezMargaret A Vizzard
Aug 18, 2009·Autonomic Neuroscience : Basic & Clinical·Vladimir P ZagorodnyukNick J Spencer
Sep 15, 2011·Developmental Neurobiology·Robert W HamillMargaret A Vizzard
Jun 11, 2011·Neurourology and Urodynamics·Anthony KanaiWilliam de Groat
Dec 22, 2009·Neurourology and Urodynamics·William C de Groat, Naoki Yoshimura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.