Alterations in neurotransmitter activity after acute and chronic ethanol treatment: studies of transmitter interactions

Alcoholism, Clinical and Experimental Research
W A HuntH Wixon


Acute and chronic ethanol treatment has multiple effects on the neurotransmitter systems in the nigrostriatal complex. A single dose of ethanol increases striatal dopamine release at low doses, but depresses it at high doses. In ethanol-dependent rats, dopamine release is accelerated during intoxication, but is reduced during a withdrawal syndrome. Concomitantly, high-affinity choline uptake, an index of cholinergic activity, is elevated at times when dopamine release is depressed. Changes in dopaminergic or cholinergic receptor activity do not induce or result from these effects. Neither has a role for GABA or substance P yet been implicated. The data suggest that interactions between at least two trasmitters in the caudate nucleus may occur after acute and chronic ethanol treatment.


Aug 1, 1975·Journal of Neurochemistry·Y C Clement-CormierP Greengard
Sep 1, 1975·The Journal of Pharmacy and Pharmacology·F JavoyJ Glowinski
Dec 1, 1977·Journal of Neurochemistry·J H Darden, W A Hunt
Oct 1, 1977·Journal of Neurochemistry·L C MurrinM J Kuhar
Nov 5, 1976·Brain Research·M J BrownsteinS E Leeman
Jan 1, 1976·Journal of Neurochemistry·S J Enna, S H Snyder
Apr 1, 1974·The Journal of Pharmacy and Pharmacology·S ConsoloS Garattini
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Nov 15, 1974·Brain Research·P L McGeerE G McGeer
Sep 1, 1974·Journal of Neurochemistry·W A Hunt, E Majchrowicz
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt


Aug 1, 1982·Electroencephalography and Clinical Neurophysiology·M W Church, H L Williams
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·W A Hunt, E Majchrowicz
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·M S Dar, W R Wooles
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·T YamamuraH Ouchi
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·W A Hunt
Jan 1, 1983·Pharmacology & Therapeutics·H Kalant, A D Lê
Jan 1, 1988·Pharmacology & Therapeutics·L A Pohorecky, J Brick
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·M M SchmitzS Rudas
Mar 1, 1986·Alcohol·D Butler, F S Messiha
Jun 29, 2004·Behavioural Brain Research·Rui D S PredigerReinaldo N Takahashi
Nov 3, 1984·British Medical Journal·J De KeyserG Ebinger
Dec 1, 1986·Alcoholism, Clinical and Experimental Research·A Kochhar, C K Erickson
May 1, 1984·Alcoholism, Clinical and Experimental Research·E P Schoener
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·G Freund
Mar 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marian L LogripDorit Ron
Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·D ClausY S Ahn

Related Concepts

Acetilcolina Cusi
Alcohol Abuse
Cholinergic Receptors
Dopamine Receptor
Hypothalamic Substance P

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.