PMID: 8943115Nov 1, 1996Paper

Alterations in neurotrophin and neurotrophin-receptor localization in Hirschsprung's disease

Journal of Pediatric Surgery
J C HoehnerL Olsen

Abstract

Interactions of the trk family of tyrosine kinase receptors with neurotrophins promote growth and differentiation of nervous-system cells during development. Disturbances in neurotrophic signalling could be involved in functional or aganglionic conditions of the intestine such as Hirschsprung's disease (HD). Intestinal resection specimens from 20 children with HD and from 10 normal age-matched controls were evaluated immunocytochemically for the presence of TrkA, TrkB, and TrkC protein, and the neurotrophin ligands brain-derived neurotrophic factor [BDNF] and neurotrophin-3 (NT-3). All three neurotrophin receptors are localized with cellular specificity to the enteric nervous system of normal and proximal ganglionic HD intestine; however, none was detected in the hypertrophic nerve fibers of aganglionic HD segments. Aganglionic HD intestine lacked intense and specific TrkC and BDNF enteric ganglionic immunoreactivity. NT-3, localized to enteric plexuses and basal lamina of ganglionic intestine, was not detected in ganglion cells located at the "transitional zone" of HD intestine. These data suggest that neurotrophic influences may be involved in enteric nervous-system cellular survival and differentiation in functional intestin...Continue Reading

References

Jun 14, 1991·Cell·M Bothwell
Feb 1, 1985·American Journal of Clinical Pathology·C L Hall, P W Lampert
Sep 4, 1987·Science·R Levi-Montalcini
Oct 30, 1981·Developmental Biology·J H GreenbergA Tyl Hewitt
Apr 1, 1995·Current Opinion in Cell Biology·M Barbacid
Feb 1, 1994·Journal of Pediatric Surgery·T KurodaM Saeki
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R C MirandaC D Toran-Allerand
Oct 1, 1992·The European Journal of Neuroscience·Patrik ErnforsHåkan Persson

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Citations

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S PåhlmanE Ortoft
Jun 27, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Wendy YangPei-Lung Chen
Dec 21, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Al-QudahJ R Grider
Jan 25, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M Guraieb-TruebaJ H Marks
Nov 5, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Arjun SinghSatish Rattan
Jun 20, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Al-QudahJ R Grider
May 15, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Donald Newgreen, Heather M Young
Dec 21, 2011·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·A Gunnarsdóttir, T Wester
Feb 25, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arjun SinghSatish Rattan
Dec 4, 2003·Journal of Medicinal Chemistry·Mookda Pattarawarapan, Kevin Burgess
Dec 23, 2004·Current Problems in Surgery·Roshini Dasgupta, Jacob C Langer
Dec 2, 1999·Gastroenterology·C GiaroniG Frigo

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