PMID: 3754780Apr 2, 1986Paper

Alterations in nociception following lesions of the A5 catecholamine nucleus

Brain Research
J Sagen, H K Proudfit

Abstract

Neurons located in the nucleus raphe magnus (NRM), a region important in the control of nociception, appear to be tonically inhibited by noradrenergic (NA) neurons. Anatomical studies have suggested that the A5 catecholamine nucleus may be the primary source of noradrenergic neurons whose terminals are located in the NRM. The purpose of the present study was to examine the role of A5 neurons in the modulation of nociception. Bilateral electrolytic lesions of the A5 nuclei produced a marked and long lasting antinociception as assessed by both the tail-flick and hot-plate tests. Unilateral A5 lesions also produced a long-lasting elevation in hot-plate latency, but the elevation of tail-flick latency was smaller in magnitude and was only observed one day following the lesion. This finding is consistent with previous studies which have shown that blockade of the NA input to the NRM by the microinjection of NA antagonists also produces antinociception. These data indicate that neurons located in the A5 nucleus may be the origin of this NA projection to the NRM. The elevation in tail-flick latency observed following A5 lesions was significantly attenuated by the intrathecal injection of either the NA antagonist phentolamine or the se...Continue Reading

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Citations

Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·K L Kepler, R J Bodnar
May 1, 1992·Brain Research Bulletin·L J Sim, S A Joseph
Nov 26, 1997·European Journal of Pharmacology·C MestreT Pelissier
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Nov 12, 2003·Respiratory Physiology & Neurobiology·Evelyn H Schlenker, Aaron Prestbo
Feb 19, 2009·Neuroscience·J J Brightwell, B K Taylor
Mar 11, 2009·The Journal of Comparative Neurology·João M BrazAllan I Basbaum
Feb 27, 2018·The Journal of Physiology·Luis Gustavo A PatroneLuciane H Gargaglioni
Apr 2, 2010·Anesthesia and Analgesia·Kenzo MakinoMasahiro Umino
Jun 23, 2018·Surgical Neurology International·James I AusmanSidney Starkman

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