Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes

Aging
María Eugenia MatzkinMónica Beatriz Frungieri

Abstract

Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the occurrence of apoptotic events in the testis. To this aim, well-established mouse models with delayed (growth hormone releasing hormone-knockout and Ames dwarf mice) or accelerated (growth hormone-transgenic mice) aging were used. We hereby show that the testes of short-lived mice show a significant increase in cyclooxygenase 2 expression, PGD2 production, lipid peroxidation, antioxidant enzymes expression, local macrophages and TUNEL-positive germ cells numbers, and the levels of both pro-caspase-3 and cleaved caspase-3. In contrast, although the expression of antioxidant enzymes remained unchanged in testes of long-lived mice, the remainder of the parameters assessed showed a significant reduction. This study provides novel evidence that longevity confers anti-inflammatory, anti-oxidant and anti-apoptotic capacities to the adult testis. Oppositely, short-lived mice suffer testicular inflammatory, oxidative and apoptotic processes.

References

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Jun 5, 2004·The Journal of Biological Chemistry·Ye-Shih HoDorothy S Ho
Sep 4, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michal M MasternakAndrzej Bartke
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Citations

Dec 20, 2019·Scientific Reports·Augusto SchneiderKyle H Rohde
May 10, 2018·Andrologia·M B FrungieriM E Matzkin
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha
Nov 9, 2016·World Journal of Stem Cells·Taylor C PeakWayne J Hellstrom
Dec 21, 2018·Andrologia·María Susana Theas
Sep 7, 2017·Oxidative Medicine and Cellular Longevity·Arthur José Pontes Oliveira de AlmeidaIsac Almeida de Medeiros
Oct 10, 2020·Reviews in Endocrine & Metabolic Disorders·Edward O ListElizabeth A Jensen
Jun 18, 2021·Mechanisms of Ageing and Development·Mónica B FrungieriMaría E Matzkin
Nov 20, 2021·Pituitary·Yanrong QianJohn J Kopchick

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Methods Mentioned

BETA
gene knockout
biopsies
Laser Capture Microdissection
transgenic
PCR
MDA

Software Mentioned

ImageJ

Related Concepts

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Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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