Aug 4, 2012

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

Therapeutic Advances in Musculoskeletal Disease
Steven R Goldring

Abstract

The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint. During the evolution of the osteoarthritic process biomechanical and biological processes result in alterations in the composition, structure and functional properties of these tissues. Given the intimate contact between the cartilage and bone, alterations of either tissue will modulate the properties and function of the other joint component. The changes in periarticular bone tend to occur very early in the development of OA. Although chondrocytes also have the capacity to modulate their functional state in response to loading, the capacity of these cells to repair and modify their surrounding extracellular matrix is relatively limited in comparison to the adjacent subchondral bone. This differential adaptive capacity likely underlies the more rapid appearance of detectable skeletal changes in OA in comparison to the articular cartilage. The OA changes in periarticular bone include increases in subchondral cortical bone thickness, gradual decreases in subchondral trabeular bone mass, formation of marginal joint osteophytes, development of bone cysts and advancement of the zone of...Continue Reading

  • References76
  • Citations58

Mentioned in this Paper

Degenerative Polyarthritis
Periarticular Route of Administration
Structure of Articular Cartilage
Extracellular Matrix
Chondrocyte
Skeletal System
Entire Articular Cartilage
Bone Mineral Density Test
Soluble
Cortical Bone Surgical Material

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