Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome

Clinical Science
Concepción M AguileraAngel Gil

Abstract

The MS (metabolic syndrome) is a cluster of clinical and biochemical abnormalities characterized by central obesity, dyslipidaemia [hypertriglyceridaemia and decreased HDL-C (high-density lipoprotein cholesterol)], glucose intolerance and hypertension. Insulin resistance, hyperleptinaemia and low plasma levels of adiponectin are also widely related to features of the MS. This review focuses on lipid metabolism alterations associated with the MS, paying special attention to changes in plasma lipids and cellular fatty acid oxidation. Lipid metabolism alterations in liver and peripheral tissues are addressed, with particular reference to adipose and muscle tissues, and the mechanisms by which some adipokines, namely leptin and adiponectin, mediate the regulation of fatty acid oxidation in those tissues. Activation of the AMPK (AMP-dependent kinase) pathway, together with a subsequent increase in fatty acid oxidation, appear to constitute the main mechanism of action of these hormones in the regulation of lipid metabolism. Decreased activation of AMPK appears to have a role in the development of features of the MS. In addition, alteration of AMPK signalling in the hypothalamus, which may function as a sensor of nutrient availabilit...Continue Reading

References

Jul 1, 1995·Physiological Reviews·G M Reaven
Oct 1, 1994·Free Radical Biology & Medicine·A P Simopoulos
Jul 1, 1994·The American Journal of Clinical Nutrition·S D PhinneyC H Warden
Nov 5, 1997·Annals of the New York Academy of Sciences·N B RudermanT G Kurowski
Jan 1, 1997·Hormone Research·M D Jensen
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M ShimabukuroR H Unger
May 2, 1998·Nutrition Reviews·J M Friedman
Feb 2, 1999·The Journal of Clinical Investigation·X ChenG Boden
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Sep 14, 1999·The American Journal of Medicine·J D Brunzell, J E Hokanson
Apr 15, 2000·Nature·P G Kopelman
Jun 1, 2000·Metabolism: Clinical and Experimental·M ValleR Cañete
Jul 13, 2000·The British Journal of Nutrition·V Grill, E Qvigstad
Aug 15, 2000·Annual Review of Nutrition·C A BaileR J Martin
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·R N Bergman, M Ader
Nov 30, 2000·The Journal of Biological Chemistry·Y LeeR H Unger
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R H Unger, L Orci
May 1, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F SprangersH P Sauerwein
May 22, 2002·Nature Neuroscience·Silvana ObiciLuciano Rossetti
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Gregory R SteinbergDavid J Dyck
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Elif Arioglu OralPhillip Gorden
Jul 30, 2002·Metabolism: Clinical and Experimental·Dick C ChanP Hugh R Barrett
Sep 17, 2002·The American Journal of Cardiology·Barry J Goldstein
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Eun-Kyoung KimGabriele V Ronnett
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N Stefan, M Stumvoll
Dec 10, 2002·Annual Review of Physiology·Roger H Unger
Jan 25, 2003·Current Opinion in Lipidology·Bengt Vessby
Jan 28, 2003·Biochemical Society Transactions·Y Minokoshi, B B Kahn
Mar 4, 2003·European Journal of Endocrinology·Juan J Díez, Pedro Iglesias
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki

❮ Previous
Next ❯

Citations

Feb 22, 2012·Journal of Medicinal Chemistry·Koneni V SashidharaGitika Bhatia
Jul 30, 2009·Lipids in Health and Disease·Wai Yen Alfred LimSharifah Noor Akmal Syed Husain
Jul 17, 2013·BMC Medical Genomics·Sunshin KimKyuBum Kwack
Jul 31, 2013·Journal of Clinical Lipidology·Harold E BaysVarman T Samuel
Sep 25, 2012·Heart Failure Clinics·Bernard P C Kok, David N Brindley
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Faidon Magkos, Bettina Mittendorfer
May 5, 2009·Free Radical Biology & Medicine·Valérie TurcotJean-Claude Lavoie
Dec 23, 2008·Atherosclerosis·Mary F FeitosaIngrid B Borecki
Apr 16, 2016·Journal of Acupuncture and Meridian Studies·Min-Ho NamByung-Cheol Lee
Jun 27, 2009·Archives of Insect Biochemistry and Physiology·Coby van DooremalenJacintha Ellers
May 8, 2013·Journal of the American Geriatrics Society·Alice LaudisioRaffaele Antonelli Incalzi
Mar 14, 2013·Journal of Veterinary Internal Medicine·M Mazaki-ToviP A Schenck
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·S CoimbraA Santos-Silva
Mar 29, 2014·Australian Veterinary Journal·R A MorganC M McGowan
May 27, 2015·Clinical Biochemistry·I M KacsoG Kacso
Oct 13, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M Gil-CamposA Gil
Sep 16, 2011·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Angel GilConcepción M Aguilera
Sep 1, 2011·Expert Review of Cardiovascular Therapy·Serena Tonstad, Jean-Pierre Després
Sep 11, 2014·Food & Function·Miguel Navarro-AlarcónAhmad Agil
Aug 6, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Natalia de las HerasVicente Lahera
Jul 1, 2010·American Journal of Physiology. Endocrinology and Metabolism·Patric J D DelhantyA J van der Lely
Sep 5, 2019·Current Medicinal Chemistry·Bozidarka ZaricEsma R Isenovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Postgraduate Medical Journal
G D KolovouD V Cokkinos
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Mercedes Gil-CamposAngel Gil
The Journal of Clinical Investigation
M RodenGerald I Shulman
© 2021 Meta ULC. All rights reserved