Alterations in plasma membrane promote overexpression and increase of sodium influx through epithelial sodium channel in hypertensive platelets

Biochimica Et Biophysica Acta
Doris CerecedoClaudia Benítez-Cardoza

Abstract

Platelets are small, anucleated cell fragments that activate in response to a wide variety of stimuli, triggering a complex series of intracellular pathways leading to a hemostatic thrombus formation at vascular injury sites. However, in essential hypertension, platelet activation contributes to causing myocardial infarction and ischemic stroke. Reported abnormalities in platelet functions, such as platelet hyperactivity and hyperaggregability to several agonists, contribute to the pathogenesis and complications of thrombotic events associated with hypertension. Platelet membrane lipid composition and fluidity are determining for protein site accessibility, structural arrangement of platelet surface, and response to appropriate stimuli. The present study aimed to demonstrate whether structural and biochemical abnormalities in lipid membrane composition and fluidity characteristic of platelets from hypertensive patients influence the expression of the Epithelial Sodium Channel (ENaC), fundamental for sodium influx during collagen activation. Wb, cytometry and quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) assays demonstrated ENaC overexpression in platelets from hypertensive subjects and in relation to co...Continue Reading

References

May 1, 1976·The Journal of Clinical Investigation·P K SchickG K Chacko
Jan 1, 1990·Life Sciences·S NityanandB N Singh
Mar 1, 1991·Clinical Science·K H Le Quan SangM A Devynck
Sep 20, 1991·Cell·J M Ervasti, K P Campbell
Dec 7, 1983·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M A DevynckP Meyer
May 29, 1981·Biochemical and Biophysical Research Communications·T Montenay-GarestierC Helene
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·Laurent SchildB C Rossier
Dec 1, 1993·Thrombosis Research·S NityanandB N Singh
Aug 1, 1993·The Journal of Cell Biology·J M Ervasti, K P Campbell
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Y ChenDavid Pearce
Aug 17, 2000·Nitric Oxide : Biology and Chemistry·P Muriel, G Sandoval
Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild
Sep 24, 2004·Physiological Reviews·Alex W CohenMichael P Lisanti
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Andrew J Halayko, Gerald L Stelmack
Apr 3, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G De PergolaR Giorgino
Nov 16, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Patrizia FerroniFiorella Guadagni
Dec 21, 2007·Proceedings of the American Thoracic Society·Andrew J HalaykoReinoud Gosens
Jul 22, 2008·Nature Neuroscience·Shigeru SatoTakahisa Furukawa
Dec 18, 2009·Journal of Cell Science·Oliver ThompsonSteve J Winder
Feb 16, 2010·Journal of Atherosclerosis and Thrombosis·Pannuru PadmavathiNallanchakravarthula Varadacharyulu
Aug 31, 2012·American Journal of Physiology. Renal Physiology·Viatcheslav NesterovChristoph Korbmacher
Apr 1, 2014·European Journal of Cell Biology·Doris CerecedoArturo Ortega
Sep 17, 2014·The Journal of General Physiology·Daniel M CollierPeter M Snyder
Apr 2, 2015·PloS One·Richard R Snell
Feb 5, 2016·American Journal of Physiology. Renal Physiology·Jonathan M NizarVivek Bhalla

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