PMID: 6163842Feb 1, 1981Paper

Alterations in protein synthetic capability of nerve cells in Alzheimer's disease

Journal of Neurology, Neurosurgery, and Psychiatry
D M MannP Stanworth

Abstract

Cytoplasmic RNA content, nuclear and nucleolar volume are all significantly reduced in nerve cells of the temporal cortex in cases of Alzheimer's disease, examined both at diagnostic craniotomy and post mortem, when compared with non=demented control cases of similar age. On average, at necropsy, all three parameters are equally reduced by about 40-50%, but in biopsy cases, nuclear volume is decreased by the greatest amount (43%), followed by nucleolar volume is decreased by the greatest amount (43%), followed by nucleolar volume (36%), and cytoplasmic RNA (26%). These findings indicate that a change in protein synthesis occurs daily in the course of Alzheimer's disease which may result from a primary alteration within the nuclear apparatus.

References

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Jul 1, 1980·Neuropathology and Applied Neurobiology·S ToperP O Yates

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Citations

Jan 1, 1988·Acta Neuropathologica·J A DoeblerR E Rhoads
Mar 1, 1990·Environmental Geochemistry and Health·D R Crapper McLachlanT P Kruck
Apr 1, 1984·Journal of the Neurological Sciences·S H Robison, W G Bradley
Sep 1, 1988·Journal of the Neurological Sciences·L J MartinA Anthony
Oct 1, 1992·Journal of the Neurological Sciences·P MazzarelloF Focher
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·L J MartinA Anthony
Mar 1, 1988·Journal of Neuroscience Methods·E M Sajdel-SulkowskaC A Marotta
Jun 1, 1989·Brain Research. Molecular Brain Research·N S LangstromW C Wallace
Jan 1, 1990·Progress in Neurobiology·P J Harrison, R C Pearson
Jul 1, 1989·Mutation Research·S K JonesS H Robison
Aug 20, 1983·Lancet·M E AppleyardM M Esiri
Nov 1, 1989·Psychological Medicine·P J Harrison, R C Pearson
Nov 1, 1991·Psychological Medicine·P J HarrisonR C Pearson
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S B ZainC A Marotta
Feb 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·D M MannJ Hawkes
Mar 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·D NearyA N Davison
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
May 1, 1982·Neuropathology and Applied Neurobiology·D M Mann
Apr 1, 1989·The American Journal of Orthopsychiatry·C A Marotta
Oct 5, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rudy J CastellaniXiongwei Zhu
Apr 1, 1989·Journal of Neurochemistry·K MaschhoffM R Morrison-Bogorad
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Feb 1, 1993·Neuropathology and Applied Neurobiology·P J HarrisonR C Pearson
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Mar 9, 2019·Reviews in the Neurosciences·Caitlin NyhusVanessa Jane Hall
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A W Clark, I M Parhad
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Apr 1, 1984·Annals of Neurology·D R McLachlanU De Boni
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Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith
Jan 1, 1988·Annals of Neurology·J A DoeblerR E Rhoads

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