Alterations in pulse wave propagation reflect the degree of outflow tract banding in HH18 chicken embryos

American Journal of Physiology. Heart and Circulatory Physiology
Liang ShiSandra Rugonyi

Abstract

Hemodynamic conditions play a critical role in embryonic cardiovascular development, and altered blood flow leads to congenital heart defects. Chicken embryos are frequently used as models of cardiac development, with abnormal blood flow achieved through surgical interventions such as outflow tract (OFT) banding, in which a suture is tightened around the heart OFT to restrict blood flow. Banding in embryos increases blood pressure and alters blood flow dynamics, leading to cardiac malformations similar to those seen in human congenital heart disease. In studying these hemodynamic changes, synchronization of data to the cardiac cycle is challenging, and alterations in the timing of cardiovascular events after interventions are frequently lost. To overcome this difficulty, we used ECG signals from chicken embryos (Hamburger-Hamilton stage 18, ∼3 days of incubation) to synchronize blood pressure measurements and optical coherence tomography images. Our results revealed that, after 2 h of banding, blood pressure and pulse wave propagation strongly depend on band tightness. In particular, while pulse transit time in the heart OFT of control embryos is ∼10% of the cardiac cycle, after banding (35% to 50% band tightness) it becomes ne...Continue Reading

References

Dec 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V Hamburger, H L Hamilton
Jan 1, 1991·Circulation Research·B B KellerE B Clark
Dec 1, 1989·Circulation Research·N Hu, E B Clark
Jul 1, 1989·The American Journal of Physiology·E B ClarkR J Tomanek
Mar 1, 1986·The American Journal of Physiology·E B ClarkR Tomanek
Nov 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·J R CainV L Rogallo
Jan 15, 1984·The American Journal of Cardiology·E B ClarkG C Rosenquist
Dec 1, 1982·Circulation Research·E B Clark, N Hu
Oct 1, 1995·The American Journal of Physiology·N Hu, B B Keller
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L A TaberE B Clark
Mar 1, 1994·Journal of Biomechanics·I E Lin, L A Taber
Jul 1, 1997·The American Journal of Physiology·M Yoshigi, B B Keller
Oct 10, 1997·The American Journal of Physiology·M YoshigiB B Keller
Jan 22, 1998·The American Journal of Physiology·B B KellerJ P Tinney
Jul 7, 2000·Developmental Biology·V M ChristoffelsA F Moorman
Jul 12, 2001·Annual Review of Biomedical Engineering·L A Taber
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Steren Chabert, Larry A Taber
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kimimasa TobitaBradley B Keller
Feb 13, 2003·The Journal of Experimental Biology·Sandra Stekelenburg-de VosRobert E Poelmann
Sep 1, 1959·Circulation Research·R J BOUCEKG H PAFF
Nov 5, 2003·Nature Biotechnology·James G Fujimoto
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·E A V JonesM E Dickinson
Sep 16, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·David SedmeraRobert P Thompson
May 28, 2005·Circulation Research·Bianca C W GroenendijkRobert E Poelmann
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer L LucittiBradley B Keller
Aug 28, 2007·Development·Jennifer L LucittiMary E Dickinson
Apr 9, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·James C Culver, Mary E Dickinson

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Citations

Feb 25, 2014·Cellular and Molecular Bioengineering·Casey M JonesOwen J T McCarty
Aug 29, 2014·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi
Apr 19, 2016·Journal of Cardiovascular Development and Disease·Venkat Keshav ChivukulaSandra Rugonyi
Feb 16, 2016·Journal of Cardiovascular Development and Disease·Vinal MenonJay D Potts
Oct 16, 2015·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi
Sep 13, 2015·Biomechanics and Modeling in Mechanobiology·Sevan GoenezenSandra Rugonyi
Aug 20, 2014·Frontiers in Physiology·Madeline Midgett, Sandra Rugonyi
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Monique Y RennieSandra Rugonyi
Jan 8, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Madeline MidgettSandra Rugonyi
May 8, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Qing PanGangmin Ning
Mar 19, 2019·Journal of Anatomy·Chrysostomos PerdiosSiobhan Loughna
Nov 27, 2019·Cold Spring Harbor Perspectives in Biology·Johannes G Wittig, Andrea Münsterberg
Apr 29, 2020·Biomedical Optics Express·Shang WangKirill V Larin
Feb 24, 2017·Frontiers in Physiology·Madeline MidgettSandra Rugonyi
Feb 12, 2021·Biomedicines·Seyed Ehsan MousaviJawahar G Patil

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