PMID: 3755061Jun 11, 1986Paper

Alterations in rat alveolar surfactant phospholipids and proteins induced by administration of chlorphentermine

Biochimica Et Biophysica Acta
P R MilesJ R Wright

Abstract

Chlorphentermine is a cationic amphiphilic drug which produces a phospholipid storage disorder in rat lungs. Experiments were carried out to characterize changes in the composition of acellular alveolar lavage materials and to study possible mechanisms by which pulmonary surfactant phospholipidosis is produced by administration of the drug. Following ten daily injections of chlorphentermine (25 mg/kg body weight), there are 12.2- and 13.6-fold increases of pulmonary lavage total phospholipids and disaturated phosphatidylcholines (disaturated PC), respectively. In addition, there is a 2.8-fold increase in total protein and a 12.7-fold increase in the surfactant apoprotein group with molecular weights from 28,000 to 32,000. We measured incorporation of labeled palmitate, choline and glycerol into disaturated PC in type II cells and alveolar macrophages isolated from control and chlorphentermine-treated animals. The drug does not affect the incorporation of labeled substrates into disaturated PC in either cell type. However, in alveolar macrophages there is a decrease in the rate of intracellular degradation of recently synthesized disaturated PC in chlorphentermine-treated animals. The drug also inhibits the phospholipase-induced...Continue Reading

References

Nov 1, 1975·CRC Critical Reviews in Toxicology·H LüllmannO Wassermann
Jan 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D B GailD Massaro
Dec 1, 1979·Biochemical Pharmacology·H Lüllmann, M Wehling
Sep 27, 1976·Biochimica Et Biophysica Acta·M F Heath, W Jacobson
Oct 1, 1976·Thorax·J GlosterP Harris
Feb 28, 1985·Biochemical and Biophysical Research Communications·S L Katyal, G Singh
Mar 1, 1985·Biochimica Et Biophysica Acta·T E WeaverJ A Whitsett
Sep 1, 1973·Thorax·P SmithP S Hasleton
May 1, 1972·Analytical Biochemistry·M B Lees, S Paxman
Jan 1, 1972·The Journal of Clinical Investigation·R J MasonM Vaughan
Sep 1, 1972·The American Journal of Physiology·R J King, J A Clements
Jul 26, 1984·Biochimica Et Biophysica Acta·S L Katyal, G Singh
Dec 21, 1984·Biochimica Et Biophysica Acta·J R WrightJ A Clements
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C S HuiR S Eisenberg
Apr 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L S AngevineH M Mehendale
Jan 7, 1983·Biochimica Et Biophysica Acta·M W MagoonJ A Clements
May 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L ZychlinskiM J Reasor
May 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J King, H Martin
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S L YoungG W Brumley
Oct 28, 1981·Biochimica Et Biophysica Acta·S L Katyal, G Singh
Jan 1, 1981·Toxicology·M J Reasor
Mar 1, 1981·Experimental Lung Research·R H RaoQ N Myrvik

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Citations

Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·B PadmavathyN Devaraj
Jun 1, 1993·American Journal of Respiratory Cell and Molecular Biology·P R MilesM R Miller
Sep 30, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yukihiro Kuroda, Madoka Saito
Jun 25, 2009·ChemMedChem·Juha-Matti AlakoskelaPaavo K J Kinnunen
Nov 13, 2008·The Journal of Allergy and Clinical Immunology·Angela Haczku
Jan 1, 1995·Experimental Lung Research·M R BalaanP R Miles
Jan 14, 1999·The American Journal of Physiology·P R MilesL Huffman
Jan 1, 1987·Progress in Lipid Research·J L Harwood
May 15, 1989·Biochimica Et Biophysica Acta·M T Gutierrez-OcañaM N Recio

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