Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders

Brain Research
Jyri-Johan PaakkiVesa J Kiviniemi

Abstract

Measures assessing resting-state brain activity with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) can reveal cognitive disorders at an early stage. Analysis of regional homogeneity (ReHo) measures the local synchronization of spontaneous fMRI signals and has been successfully utilized in detecting alterations in subjects with attention-deficit hyperactivity disorder (ADHD), depression, schizophrenia, Parkinson's disease and Alzheimer's dementia. Resting-state brain activity was investigated in 28 adolescents with autism spectrum disorders (ASD) and 27 typically developing controls being imaged with BOLD fMRI and analyzed with the ReHo method. The hypothesis was that ReHo of resting-state brain activity would be different between ASD subjects and controls in brain areas previously shown to display functional alterations in stimulus or task based fMRI studies. Compared with the controls, the subjects with ASD had significantly decreased ReHo in right superior temporal sulcus region, right inferior and middle frontal gyri, bilateral cerebellar crus I, right insula and right postcentral gyrus. Significantly increased ReHo was discovered in right thalamus, left inferior frontal and anterior subcal...Continue Reading

References

Aug 1, 1995·Journal of Autism and Developmental Disorders·P C DiLavoreM Rutter
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Oct 30, 2001·Experimental Brain Research·K Mosier, I Bereznaya
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
May 10, 2003·Brain Research. Brain Research Reviews·Doris-Eva BamiouLinda M Luxon
Jun 20, 2003·NeuroImage·Vesa KiviniemiOsmo Tervonen
Sep 30, 2003·The American Journal of Psychiatry·Ralph-Axel MüllerEric Courchesne
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Aug 24, 2005·The European Journal of Neuroscience·E Jansson-VerkasaloP Korpilahti
Jan 6, 2006·Journal of Autism and Developmental Disorders·Grace Iarocci, John McDonald
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel P KennedyEric Courchesne
Jun 23, 2006·Nature Reviews. Neuroscience·Narender Ramnani
Jul 11, 2006·Brain Research·Akiko MizunoRalph-Axel Müller
Oct 19, 2006·Neuroreport·Vladimir L CherkasskyMarcel Adam Just
Apr 24, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Marja-Leena MattilaIrma Moilanen
May 29, 2007·Epilepsy & Behavior : E&B·John R Hughes
Jun 29, 2007·Neuroscience Letters·Hamid Reza NaghaviLars Nyberg
Nov 6, 2007·Human Brain Mapping·Gopikrishna DeshpandeXiaoping Hu
Dec 15, 2007·Neuroscience Letters·Alan SimmonsMurray B Stein
Dec 18, 2007·NeuroImage·Daniel P Kennedy, Eric Courchesne
Mar 8, 2008·Journal of Autism and Developmental Disorders·Sanna KuusikkoIrma Moilanen
May 20, 2008·Journal of Neuroscience Methods·Xiang-Yu LongYu-Feng Zang
Jun 17, 2008·Brain Research·Natalia M KleinhansEric Courchesne
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Nov 19, 2008·Social Cognitive and Affective Neuroscience·Daniel P Kennedy, Eric Courchesne
Jan 17, 2009·NeuroImage·Aviv MezerYaniv Assaf
Feb 12, 2009·Journal of Autism and Developmental Disorders·Sanna KuusikkoIrma Moilanen
Jul 15, 2009·European Child & Adolescent Psychiatry·Marja-Leena MattilaIrma Moilanen

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Citations

Dec 4, 2013·European Child & Adolescent Psychiatry·Marianne OldehinkelMaarten Mennes
Jul 27, 2012·Neuroscience Bulletin· WurinaShi-Gang Zhao
Jan 1, 2011·Brain Connectivity·Ali-Mohammad Golestani, Bradley G Goodyear
Oct 19, 2011·Brain : a Journal of Neurology·Jeffrey S AndersonJanet E Lainhart
Feb 6, 2014·Neuropsychology Review·Jose O MaximoRajesh K Kana
Oct 21, 2014·Current Behavioral Neuroscience Reports·Leslie A HulvershornMindy Westlund
Jun 21, 2014·Journal of Neurosurgery. Pediatrics·Duc Ha HoangAlexandre Krainik
Mar 30, 2013·Annual Review of Clinical Psychology·Nina de Lacy, Bryan H King
Nov 1, 2011·Expert Opinion on Medical Diagnostics·Naama Barnea-Goraly, Antonio Hardan
Jun 11, 2015·Autism Research : Official Journal of the International Society for Autism Research·Dina R Dajani, Lucina Q Uddin
Feb 25, 2015·European Archives of Psychiatry and Clinical Neuroscience·Dusan HirjakRobert C Wolf
Sep 29, 2015·NeuroImage. Clinical·R L MoseleyM Rubinov
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Yudong ZhangTi-Fei Yuan
Aug 13, 2011·Psychiatry Research·Changjian QiuQiyong Gong
Apr 13, 2010·Neuroscience Letters·Dinesh K ShuklaRalph Axel Müller
Nov 26, 2015·Frontiers in Neuroscience·Anila M D'Mello, Catherine J Stoodley

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