Alterations in renal function induced by aflatoxin B1 in the rat

Toxicology and Applied Pharmacology
M E GrosmanE A Rodriguez Garay

Abstract

The effects of aflatoxin B1 (AFB1) on renal function were determined in adult male Wistar rats by in vivo and in vitro studies. In vivo studies demonstrated that AFB1 decreased glomerular filtration rate, tubular reabsorption of glucose, and tubular transport for p-amino-hippurate. Furthermore, AFB1 pretreatment increased urinary excretion of sodium and potassium and urinary gamma-glutamyl transferase content. In vitro studies showed that slices of renal cortical tissue obtained from AFB1-treated rats (100 microgram/kg) exhibited a diminished capacity to accumulate p-aminohippurate. On the other hand, total water content of tissue, amount of extracellular water, and intracellular sodium were increased. Intracellular potassium was diminished by treatment with AFB1. Although the molecular species responsible for the effects is not known, these results indicated that AFB1 is nephrotoxic in the rat following a single low dose (100 microgram/kg body wt, ip).

References

Feb 1, 1976·Toxicology and Applied Pharmacology·T C Campbell, J R Hayes
Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·J Diézi, J Biollaz
Oct 1, 1978·Acta Pharmacologica Et Toxicologica·R G AroraA Bergman
Sep 1, 1977·Journal of Agricultural and Food Chemistry·J R HayesT C Campbell
May 1, 1973·Poultry Science·H T TungP B Hamilton
Oct 1, 1980·Kidney International·C WestenfelderN A Kurtzman
Jun 1, 1980·Food and Cosmetics Toxicology·J LüthyC Schlatter
Aug 1, 1980·Toxicology and Applied Pharmacology·Z A Wong, D P Hsieh
Nov 1, 1980·Kidney International·W O BerndtR D Phillips
Jan 1, 1959·The American Journal of Physiology·E C FOULKES, B F MILLER
Apr 1, 1950·The American Journal of Physiology·R J CROSS, J V TAGGART

❮ Previous
Next ❯

Citations

Jan 1, 1992·Archives of Toxicology·L TrumperM M Elías
Apr 1, 1986·European Journal of Drug Metabolism and Pharmacokinetics·M Van der GraaffD D Breimer
Jun 1, 1984·Toxicology Letters·M E GrosmanE A Rodriguez Garay
Apr 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K W BeersW E Huff
Feb 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K W BeersW G Bottje
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T QuezadaJ L Reyes
May 10, 2011·Bulletin of Environmental Contamination and Toxicology·Biruck DesalegnAkio Koizumi
Sep 16, 2015·International Journal of Environmental Research and Public Health·Na LiangYi Geng
Dec 17, 2008·Molecular Nutrition & Food Research·Angela Mally, Wolfgang Dekant
Mar 13, 2014·Journal of the Science of Food and Agriculture·Wei WeiYu Zhou
Jul 4, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Zhiqiang JiaZhihui Chen
Jul 13, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A TreiberM Clozel
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin Klvana, Urban Bren
Jul 1, 2020·Environmental Science and Pollution Research International·Magdy M ElgioushyEmad A Hashish
Apr 4, 2021·Toxins·Alexandros YiannikourisColm Anthony Moran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.