Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat

Biology of Reproduction
L WilsonM Y Dawood


Prostaglandins (PGs) are thought to have an important function in the initiation and/or propagation of parturition. To define the relationship of individual PGs to one another and compare their alterations with gestational age, PGF, PGE, 6-keto-PGF1 alpha (6KF) and thromboxane B2 (TxB2) were measured in uterine and placental tissue and uterine venous plasma of rats at Days 15, 18, 19, 20, and 21 of pregnancy and at delivery (Day 21 1/2). In addition, concomitant measurements of peripheral plasma estradiol (E2), estrone (E1) and progesterone (P) and pituitary oxytocin (OT) content, putative regulators and/or modulators of PG metabolism, were determined. Significant enhancements (P less than 0.05) in uterine 6KF, TxB2, PGF and PGE concentrations (ng/mg DNA) were detected by Day 20 compared to Day 15 of pregnancy and further dramatic increases were found on Day 21 and at delivery. Although uterine 6KF was present in the highest concentrations, PGF showed the greatest increment from Day 15 to delivery. No alterations in uterine venous plasma PGE or PGF concentration were found with gestational age but 6KF and TxB2 showed significant increases at delivery. The placental concentrations of PGs were approximately 1/50 of uterine tissue...Continue Reading


Mar 13, 1999·American Journal of Primatology·T NguyenL Wilson
Apr 1, 1983·Prostaglandins·T GimenezD M Henricks
Sep 1, 1990·Prostaglandins·H E CejtinL Wilson
Sep 1, 1987·Prostaglandins, Leukotrienes, and Medicine·L Wilson, R Lindsey
Mar 1, 1989·Neurotoxicology and Teratology·D J Bonthius, J R West
Jan 15, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E GonzálezM Gimeno
Mar 6, 2013·BMC Pregnancy and Childbirth·Nardhy Gomez-LopezDavid M Olson
Jun 9, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Stephen T AndersonJon D Curlewis
Oct 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L Mårtensson
Jan 1, 1987·The American Journal of Physiology·J G Douglas

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