PMID: 11907195Mar 22, 2002Paper

Alterations in responses of ventral pallidal neurons to excitatory amino acids after long-term dopamine depletion

The Journal of Pharmacology and Experimental Therapeutics
Michael S TurnerT C Napier

Abstract

The present study explored the possibility that excitatory amino acid (EAA) sensitivity within the ventral pallidum (VP) is altered by long-term removal of dopamine (DA). Electrophysiological experiments were conducted in chloral hydrate-anesthetized rats 21 to 28 days after they received unilateral substantia nigra injections of the dopaminergic toxin 6-hydroxydopamine (6-OHDA). VP neurons increased firing at low microiontophoretic ejection currents of the EAA agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA); however, high currents decreased action potential amplitude and rapidly caused cessation of neuronal firing. These responses likely reflected the induction of depolarization block for they were reversed by coiontophoresis of the hyperpolarizing transmitter gamma-aminobutyric acid (GABA) at ejection current levels that normally suppressed firing. The ability of NMDA and AMPA to induce such inactivation was greater in the VP of 6-OHDA-lesioned hemispheres, but unchanged in reserpinized rats, verifying that the alterations in responding to NMDA were the result of chronic, rather than acute, DA removal. The adaptations do not appear to be the consequence of a diminished ...Continue Reading

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Citations

Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John McDaidT Celeste Napier
May 31, 2013·Neuroreport·Steven M GravesT Celeste Napier
Nov 26, 2005·The European Journal of Neuroscience·Amy J TindellJ Wayne Aldridge
Apr 11, 2015·Progress in Neurobiology·David H RootT Celeste Napier
Apr 10, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Celeste NapierAmanda L Persons

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