Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio)

Aquatic Toxicology
Lianguo ChenBingsheng Zhou

Abstract

This study examined the disruptive effect of exposure to polybrominated diphenyl ethers (PBDEs) on retinoid content in zebrafish (Danio rerio). Adult zebrafish were exposed to an environmentally relevant concentration (0.45 μg/L) and a higher concentration (9.6 μg/L) of DE-71 for 60 days. Retinoid content and gene transcription levels were examined in female zebrafish. PBDE exposure caused a significant decrease of retinyl ester content in the intestine and a downregulation of intestinal cellular retinol binding protein gene transcription (CRBP1a). In the liver, retinyl ester content was significantly decreased, while retinol content was increased. An upregulation of liver CRBP2a and retinol binding protein (RBP) gene transcription and an increased level of RBP protein were observed. In the eyes, both the retinal and retinyl ester content were increased and CRBP1a gene transcription was upregulated. However, the gene encoding for retinal dehydrogenase (RALDH2), responsible for retinoic acid synthesis, was downregulated in the eyes. CYP26a, the gene responsible for retinoic acid degradation, was upregulated, which indicated an increased level of retinoic acid. In the ovaries, the increased deposition of retinoids was also observ...Continue Reading

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Citations

Mar 22, 2014·Aquatic Toxicology·Jian HanBingsheng Zhou
Jan 28, 2014·The Science of the Total Environment·Nancy BlüthgenKarl Fent
Dec 7, 2013·Environmental Toxicology and Chemistry·Yu-Jie DaiDe-Sheng Pei
Feb 13, 2013·Environmental Toxicology and Chemistry·Lianguo ChenBingsheng Zhou
Mar 7, 2014·Environmental Toxicology and Chemistry·Liqin YuBingsheng Zhou
Jan 15, 2015·General and Comparative Endocrinology·Liqin YuChunsheng Liu
Aug 1, 2014·Environmental Science and Pollution Research International·Jing ZhaoDaqiang Yin
Jun 26, 2020·Aquatic Toxicology·Lianguo Chen

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