Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer

Pathology Oncology Research : POR
Ákos GasparicsAttila Sebe

Abstract

Suppressor of cancer cell invasion (SCAI) has been originally characterized as a tumor suppressor inhibiting metastasis in different human cancer cells, and it has been suggested that SCAI expression declines in tumors. The expression patterns and role of SCAI during physiological and pathophysiological processes is still poorly understood. Earlier we demonstrated that SCAI is regulating the epithelial-mesenchymal transition of proximal tubular epithelial cells, it is downregulated during renal fibrosis and it is overexpressed in Wilms' tumors. Here we bring further evidence for the involvement of SCAI during cell plasticity and we examine the prognostic value and expression patterns of SCAI in various tumors. SCAI prevented the activation of the SMA promoter induced by angiotensin II. SCAI expression decreased in a model of endothelial-mesenchymal transition and increased during iPS reprogramming of fibroblasts. During renal fibrosis SCAI expression declined, as evidenced in a rat model of renal transplant rejection and in TGF-β1 overexpressing transgenic mice. High expression of SCAI correlated with better survival in patients with breast and lung cancers. Intriguingly, in the case of other cancers (gastric, prostate, colorec...Continue Reading

References

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Citations

Apr 10, 2020·International Journal of Molecular Sciences·Jacek BajPiero Portincasa
May 7, 2019·Frontiers in Pharmacology·Attila FinthaAttila Sebe
Dec 18, 2020·Technology in Cancer Research & Treatment·Yongqin CaiHonggang Wang

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Methods Mentioned

BETA
SMA
transfection
Assay
Protein Assay
PCR
chips
chip
transgenic

Software Mentioned

NuclearQuant
affy Bioconductor
R
3DHistech Pannoramic Viewer

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