Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice

The European Journal of Neuroscience
Simone M SmitsMarten P Smidt

Abstract

Pitx3 deficiency in mice causes a dramatic loss of dopaminergic neurones located in the substantia nigra pars compacta during development. This early disruption of the nigrostriatal pathway in Pitx3-deficient mice is characterized by increased spontaneous home-cage activity levels during the habitual sleep phase of these animals. These findings are reminiscent of the spontaneous hyperactivity in mice neonatally lesioned with 6-hydroxydopamine, which is caused by an extensive serotonergic hyperinnervation of the striatum. The present study investigated whether an imbalance between dopamine (DA) and serotonin (5-HT) signalling is involved in the behavioural phenotype of Pitx3-deficient mice. Serotonergic hyperinnervation was demonstrated by increased [3H]-citalopram autoradiographic binding specifically in the dorsal striatum of adult Pitx3-deficient mice, indicating alterations in 5-HT transporter levels that correlated to DA dysfunction in Pitx3 deficiency. In addition, stimulus-induced release of DA and 5-HT indicated an altered balance between these neurotransmitters in the dorsal striatum of Pitx3-/- mice. To determine whether the increased 5-HT signalling was involved in the spontaneous hyperactivity during the light phase ...Continue Reading

References

Mar 7, 1998·Journal of Neurochemistry·R M KostrzewaL Descarries
Jan 6, 2000·Progress in Neurobiology·C M PortasR Ursin
Jun 14, 2002·Experimental Neurology·Ronald DeumensJos Prickaerts
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Irene NunesStephen P Goff
Jun 28, 2003·Brain Research. Molecular Brain Research·Dong-Youn HwangKwang-Soo Kim
Aug 10, 2004·Cell and Tissue Research·Marten P SmidtJ Peter H Burbach
Feb 15, 2005·Brain Research. Brain Research Reviews·George R BreeseBonita L Blake
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dong-Youn HwangKwang-Soo Kim
Sep 6, 2005·Molecular and Cellular Neurosciences·Simone M SmitsMarten P Smidt
Nov 5, 2005·Journal of Neurochemistry·Pepijn van den MunckhofJacques Drouin
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kafui DzirasaMiguel A L Nicolelis

❮ Previous
Next ❯

Citations

Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeff A BeelerXiaoxi Zhuang
Dec 25, 2012·Disease Models & Mechanisms·Matthew C HavrdaKathryn B Holroyd
Sep 1, 2011·Progress in Neurobiology·Philippe HuotJonathan M Brotchie
Apr 14, 2015·Developmental Psychobiology·Gale A Kleven, Seanceray A Bellinger
Oct 16, 2010·Prion·Keith M GunapalaAndrew D Steele
Mar 10, 2015·ACS Chemical Neuroscience·Vera NiederkoflerSusan M Dymecki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.