PMID: 7514152May 15, 1994Paper

Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer

International Journal of Cancer. Journal International Du Cancer
F el AtiqG Pommier

Abstract

It has been reported that insulin-like growth factor (IGF) II is associated with human primary colorectal tumors and colon-carcinoma cell lines. Here, we examine alterations in circulating levels of IGFs and IGF binding proteins (IGFBPs) in patients with colorectal carcinoma, and compare them to age- and nutrition-adjusted references. We report (i) an increase in serum IGF-II concentrations (about 2-fold), whereas IGF-I concentrations are regarded as normal when aging is taken into account; (ii) an apparent increase in serum IGFBP-3 levels when compared to those of healthy elderly subjects, IGFBP-3 only being detected in the 150-kDa IGFBP ternary complex as in normal serum; (iii) abnormally elevated serum IGFBP-2 levels taking into account the apparent concentrations of IGFBP-3. This simultaneous elevation of IGFBP-3 and IGFBP-2 in the serum of patients with colorectal tumors appears to be unique in that it reflects a break in the inverse relationship between the serum IGFBP-3 and IGFBP-2 levels that is observed in normal and in several physiopathological conditions. Moreover, it enables a distinction to be made between 76.5% (13/17) of patients with colorectal carcinoma and normal adults, age-related healthy aged and malnouris...Continue Reading

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Citations

Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·O ManousosC Mantzoros
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·S KansraE Friedman
Jan 15, 2005·International Journal of Colorectal Disease·Rajaraman DuraiMarc C Winslet
Jul 1, 1996·Baillière's Clinical Endocrinology and Metabolism·A J Donaghy, R C Baxter
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·C Camacho-Hübner
Oct 13, 2001·Trends in Molecular Medicine·S A Bustin, P J Jenkins
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sarah M DunlapWei Zhang
Oct 21, 1999·Journal of the National Cancer Institute·L BubendorfO P Kallioniemi
Dec 13, 2012·Cancer Research·Swadesh K DasPaul B Fisher
Dec 20, 2008·Molecular Endocrinology·Kenichi MiyakoPinchas Cohen
Aug 27, 2009·Biologics : Targets & Therapy·Colin R Lindsay, Tr Jeffry Evans
Nov 28, 2013·Experimental and Molecular Pathology·Miloš ŠunderićOlgica Nedić
Oct 26, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C La VecchiaA Tavani
Jan 25, 2006·Clinical Endocrinology·P J JenkinsS M Shalet
Aug 9, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A Juncker-JensenJ S Jepsen
Sep 13, 2005·Biochemical and Biophysical Research Communications·Randy J LevittMichael Pollak
Jun 13, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ulrick EspelundJan Frystyk
Jan 27, 2015·Journal of Cell Communication and Signaling·Steven W YauVincenzo C Russo
Mar 17, 2015·Frontiers in Endocrinology·Adam Pickard, Dennis J McCance
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatKevin M Slawin
Oct 28, 2008·Virchows Archiv : an International Journal of Pathology·Gianluca MarucciVincenzo Eusebi
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Jyh-Ming LiouJaw-Town Lin
Nov 27, 2019·Intestinal research·Hyung-Hoon Oh, Young-Eun Joo

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