Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide

Neurobiology of Disease
Gregory L HolmesJeremy Barry

Abstract

There is a well-described association between infantile epilepsy and pervasive cognitive and behavioral deficits, including a high incidence of autism spectrum disorders. Despite the robustness of the relationship between early-life seizures and the development of autism, the pathophysiological mechanism by which this occurs has not been explored. As a result of increasing evidence that autism is a disorder of brain connectivity we hypothesized that early-life seizures would interrupt normal brain connectivity during brain maturation and result in an autistic phenotype. Normal rat pups underwent recurrent flurothyl-induced seizures from postnatal (P)days 5-14 and then tested, along with controls, for developmental alterations of development brain oscillatory activity from P18-P25. Specifically we wished to understand how normal changes in rhythmicity in and between brain regions change as a function of age and if this rhythmicity is altered or interrupted by early life seizures. In rat pups with early-life seizures, field recordings from dorsal and ventral hippocampus and prefrontal cortex demonstrated marked increase in coherence as well as a decrease in voltage correlation at all bandwidths compared to controls while there we...Continue Reading

References

Sep 2, 1996·Brain Research. Developmental Brain Research·J C NeillG L Holmes
Jul 27, 1999·American Journal of Human Genetics·N RischR M Myers
May 23, 2002·Brain : a Journal of Neurology·Patrick F BoltonAndrew Pickles
Sep 11, 2002·Trends in Neurosciences·Sarit Avishai-ElinerTallie Z Baram
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Jan 18, 2005·Biological Psychiatry·Ruth A Carper, Eric Courchesne
Mar 31, 2005·Journal of Autism and Developmental Disorders·David CohenDelphine Héron
Apr 12, 2005·Neuron·Athanassios G SiapasMatthew A Wilson
Mar 24, 2006·The European Journal of Neuroscience·Elena IsaevaGregory L Holmes
Sep 15, 2006·Behavioural Brain Research·Sheryl S MoyJacqueline N Crawley
Mar 21, 2007·Neurotoxicology·Barbara ClancyK J S Anand
Jul 6, 2007·The European Journal of Neuroscience·Jun-Li ZhouGregory L Holmes
Oct 25, 2007·Human Brain Mapping·Robert W ThatcherCarl J Biver
Mar 12, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert CobenRobert J Barry
Oct 30, 2008·Frontiers in Human Neuroscience·Floris P de LangeIvan Toni
Mar 6, 2009·Epilepsia·Andréy MazaratiRaman Sankar
Mar 25, 2009·Human Brain Mapping·Ali MazaheriOle Jensen
Apr 7, 2009·Experimental Neurology·Havisha B KarnamGregory L Holmes
Apr 28, 2009·Epilepsy Research·Havisha B KarnamGregory L Holmes
May 21, 2009·Pediatric Research·Sarah J Spence, Mark T Schneider
Sep 15, 2009·Current Biology : CB·Tobias H DonnerAndreas K Engel
Apr 14, 2010·The European Journal of Neuroscience·Elena IsaevaGregory L Holmes
May 12, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A N BhatR J Landa
Jul 29, 2010·Human Molecular Genetics·Richard AnneyJoachim Hallmayer
Aug 19, 2010·Autism Research : Official Journal of the International Society for Autism Research·Cathy LéveilléRoger Godbout
Mar 19, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yijun LiFrances E Jensen
Mar 23, 2011·Current Neurology and Neuroscience Reports·Roberto Tuchman, Michael Cuccaro
May 24, 2011·Brain : a Journal of Neurology·Marcella M LucasRod C Scott
Jul 6, 2011·Archives of General Psychiatry·Joachim HallmayerNeil Risch
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan K KleenPierre-Pascal Lenck-Santini
Nov 10, 2011·JAMA : the Journal of the American Medical Association·Eric CourchesneKaren Pierce
Jan 12, 2012·Nature Reviews. Neuroscience·Markus SiegelAndreas K Engel
Mar 15, 2012·Nature Communications·Francesca SuccolAndrea Barberis
Aug 15, 2012·Developmental Neuropsychology·Robert W Thatcher
Oct 16, 2012·Neurobiology of Disease·A E HernanE Isaeva

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Citations

Mar 25, 2016·Expert Review of Neurotherapeutics·Chao DuXuenfeng Wang
Sep 1, 2015·Epilepsy Currents·Carl E Stafstrom, Tim A Benke
Aug 22, 2016·Seminars in Pediatric Neurology·Gregory L Holmes
Jan 15, 2017·Physiological Reports·Lezio S Bueno-JuniorOsvaldo D Uchitel
Aug 29, 2019·Epilepsy Currents·Patrick A Forcelli
Aug 16, 2016·Journal of Child Neurology·Jeremy M Barry, Gregory L Holmes
May 10, 2019·Frontiers in Neuroscience·Shivani C KharodShilpa D Kadam
Jan 1, 2017·International Journal of Epilepsy·Gregory SmithJoaquin N Lugo
May 4, 2018·Frontiers in Pharmacology·Yuka KasaharaRyuta Koyama
Jul 16, 2019·Restorative Neurology and Neuroscience·Dongxia TaoMei Zhao
Nov 18, 2020·Annals of Neurology·Janet S SoulUNKNOWN Boston Bumetanide Trial Group
Nov 12, 2021·Neurologia Medico-chirurgica·Satoshi MaesawaRyuta Saito

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