PMID: 8941540Nov 1, 1996Paper

Alterations in structure of elastic laminae of rat pulmonary arteries in hypoxic hypertension

Journal of Applied Physiology
S Q Liu

Abstract

The effect of hypoxic hypertension on the remodeling process of the elastic laminae of the rat hilar pulmonary arteries (PAs) was studied by electron microscopy. Rats were exposed to hypoxia (10% O2) for periods of 0.5, 2,6,12,48,96,144, and 240 h. Changes in the structure of the PA elastic laminae were examined and analyzed with respect to changes in the PA wall tensile stress. The PA blood pressure increased rapidly within the first several hours of hypoxia and reached a stable level within 2 days, whereas the PA wall tensile stress increased initially due to elevated blood pressure and then decreased after 48 h due to vessel wall thickening and returned to the control level after 4 days. In association with these changes, the elastic laminae, which appeared homogeneous in normal control rats, changed into structures composed of randomly oriented filaments and edematous contents with an increase in the volume during the early period of hypoxia and regained their homogeneous appearance and normal volume after 4 days. The changes in the elastic laminae were correlated with changes in the tensile stress. These changes were associated with a transient decrease in the stiffness of the PAs. In hypoxic rats given nifedipine, no chan...Continue Reading

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Citations

Jul 21, 1999·Journal of Biomechanical Engineering·S Q Liu
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S BonnetJ P Savineau
Nov 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ryan W KobsNaomi C Chesler
Sep 1, 2005·Annals of Biomedical Engineering·Yanhang ZhangRobin Shandas
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·W HuangY C Fung
Feb 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Gary S Krenz, Christopher A Dawson
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jeremy GoldmanShu Q Liu
May 15, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sukrutha ChettimadaSachin A Gupte
Aug 30, 2003·Circulation Research·Vincent SauzeauPierre Pacaud
Nov 18, 2003·Pediatric Pulmonology·Donald W ThibeaultIkechukwu I Ekekezie
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·W HuangY C Fung
Jan 6, 2007·Journal of Cardiovascular Pharmacology·Kohtaro AbeHiroaki Shimokawa
Oct 27, 2015·Scientific Reports·Jiaolong WangYan Chun Li

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