Alterations in sympathetic neuroeffector transmission to mesenteric arteries but not veins in DOCA-salt hypertension.

Autonomic Neuroscience : Basic & Clinical
Jinwoo ParkGreg M Swain

Abstract

We studied hypertension-associated changes in prejunctional alpha(2) adrenergic receptor (alpha(2)-AR) function using amperometry to monitor in vitro norepinephrine (NE) measured as oxidation currents. Vasoconstriction was measured using video imaging. NE release was induced by electrical stimulation of sympathetic nerves associated with mesenteric arteries (MA) and veins (MV) of sham and DOCA-salt hypertensive rats. NE oxidation currents were larger in DOCA-salt compared to sham MA; there were no differences between currents in sham and DOCA-salt MV. Increases in NE oxidation currents followed a multi-exponential time course in sham MA. In DOCA-salt MA and sham and DOCA-salt MV, the time course was mono-exponential. Yohimbine (alpha(2)-AR antagonist, 1 microM), caused a mono-exponential increase in NE oxidation currents in sham and DOCA-salt MA. Yohimbine increased NE oxidation currents and constrictions more in sham compared to DOCA-salt MA and compared to MV. UK 14,304 (alpha(2)-AR agonist, 1.0 microM), reduced currents less in DOCA-salt MA and sham and DOCA-salt MV compared to sham MA. Prazosin (alpha(1)-AR antagonist, 0.1 microM) did not alter NE oxidation currents. Prazosin inhibited constrictions more in DOCA-salt compar...Continue Reading

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Citations

Mar 19, 2013·PloS One·Doreen JankeVera Jankowski
Jul 6, 2013·Canadian Journal of Physiology and Pharmacology·Saad EnouriRon Johnson
Sep 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sachin S Kandlikar, Gregory D Fink
Feb 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Sutheera SangsiriHui Xu
Sep 3, 2013·Nitric Oxide : Biology and Chemistry·Tushar V GadkariMahesh S Joshi
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Nov 28, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sutheera SangsiriJames J Galligan
Jun 14, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John P CollisterJohn W Osborn

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