Alterations in synaptosomal calcium concentrations after rapid eye movement sleep deprivation in rats

Neuroscience
B N Mallick, Seema Gulyani

Abstract

Rapid eye movement sleep deprivation alters behavioral and physiological, as well as cellular functioning and responsiveness. Since intracellular calcium concentration plays an important role in regulating cellular functions, it was hypothesized that such deprivation might induce changes in intracellular calcium concentration. Therefore, in this study, rats were deprived of rapid eye movement sleep by the flower-pot technique, and total, bound and free calcium concentrations were estimated in synaptosomal preparations from the cerebrum, cerebellum, brainstem, midbrain, pons and medulla. Rapid eye movement sleep deprivation was continued for two or four days and suitable control experiments were conducted to rule out the effects of non-specific factors. Total calcium concentration increased in the brainstem but showed a decrease in the cerebellum and cerebrum. After four days deprivation, the free calcium concentration always decreased; however, the bound calcium concentration decreased in the cerebrum and cerebellum but increased in the brainstem. After two days' deprivation, the medulla was the only region where the bound calcium increased while the free form decreased; only the free form decreased in the pons, while the midbr...Continue Reading

References

Apr 1, 1977·Behavioral Biology·W Fishbein, B M Gutwein
Jun 1, 1975·Archives of General Psychiatry·G W Vogel
Mar 1, 1979·Journal of Neurochemistry·W K Schmidt, E L Way
Jun 1, 1992·Current Opinion in Neurobiology·D D GintyM E Greenberg
Jun 1, 1992·Journal of Neuroscience Research·S L YatesP M Lippiello
May 1, 1991·Pharmacology, Biochemistry, and Behavior·M Thakkar, B N Mallick
Jan 1, 1990·Current Topics in Cellular Regulation·H Rasmussen, J E Rasmussen
May 7, 1990·Brain Research·B N MallickH Fahringer
Sep 1, 1989·Behavioral and Neural Biology·P Gisquet-Verrier, C Smith
Jan 1, 1988·Annual Review of Physiology·D R Yingst
Jan 1, 1988·Fundamental & Clinical Pharmacology·P Lapalus, P P Elena
Feb 1, 1989·Sleep·C A KushidaA Rechtschaffen
Aug 1, 1986·Pharmacology, Biochemistry, and Behavior·E MogilnickaA M Coenen
Feb 3, 1987·Brain Research·G Yanik, M Radulovacki
Jan 1, 1986·Progress in Neurobiology·B L Jacobs
Jan 1, 1986·Physiology & Behavior·E L van Luijtelaar, A M Coenen
Sep 1, 1968·Journal of Personality and Social Psychology·R D Cartwright, L J Monroe
Jul 1, 1974·Pharmacology, Biochemistry, and Behavior·W B MendelsonR J Wyatt
Jun 1, 1967·The Journal of Nervous and Mental Disease·S R Clemes, W C Dement
Jan 1, 1981·Reviews of Physiology, Biochemistry and Pharmacology·A B Borle
Mar 1, 1995·Neuroscience Research·B N MallickR Gangabhagirathi
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·B N Mallick, S Gulyani
Jun 1, 1993·Current Opinion in Neurobiology·R PennerM Hoth
Mar 1, 1993·Journal of Sleep Research·S Gulyani, B N Mallick
Jun 1, 1993·Journal of Sleep Research·J M Krueger, F Obál

❮ Previous
Next ❯

Citations

Oct 17, 2002·Journal of Biosciences·Birendra N MallickDinesh Pal
Dec 5, 1998·Neurochemistry International·H V Anupama Adya, B N Mallick
May 10, 2007·Journal of Cognitive Neuroscience·Kevin R PetersCarlyle T Smith
Apr 13, 2011·Sleep Medicine Reviews·Birendra N Mallick, Abhishek Singh
Sep 2, 2003·Journal of Neuroscience Research·Sudipta MajumdarBirendra N Mallick
Nov 22, 2007·Journal of Neurochemistry·Stephany JonesChiara Cirelli
Aug 5, 2006·Neuroscience·S BiswasB N Mallick
Dec 5, 2000·Brain Research·C Cirelli, G Tononi
Jan 18, 2003·Sleep Medicine Reviews·Chiara Cirelli, Giulio Tononi
Aug 22, 2006·Sleep Medicine Reviews·Chiara Cirelli
May 27, 1999·Annals of Medicine·C Cirelli, G Tononi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.