Alterations in Synovial Fluid Biomarker Levels in Knees With Meniscal Injury as Compared With Asymptomatic Contralateral Knees

The American Journal of Sports Medicine
Andrew J ClairEric J Strauss

Abstract

Changes in the joint microenvironment after an injury to the articular surface of the knee have been implicated in the pathogenesis of osteoarthritis. While prior studies focused on changes in this microenvironment after anterior cruciate ligament ruptures, few have explored the biomarker changes that occur in the setting of meniscal injuries. To determine whether meniscal injury results in significant alterations to synovial fluid biomarker concentrations as compared with noninjured contralateral knees. Additionally, to explore the relationship between synovial fluid biomarkers and the degree of cartilage injury seen in these patients. Cross-sectional study; Level of evidence, 3. Patients undergoing surgery for unilateral meniscal injury were prospectively enrolled from October 2011 to December 2016, forming a cohort that had synovial fluid samples collected from both the injured knee and the contralateral uninjured knee at the time of meniscal surgery. Synovial fluid samples were collected just before incision, and the concentrations of 10 biomarkers of interest were determined with a multiplex magnetic bead immunoassay. The concentrations of synovial fluid biomarkers from the operative and contralateral knees were compared. ...Continue Reading

References

Oct 1, 1990·Acta Orthopaedica Scandinavica·A HedeS Sonne-Holm
Jan 4, 2001·Immunological Reviews·P ScapiniM A Cassatella
Jun 27, 2001·Allergy and Asthma Proceedings·P Conti, M DiGioacchino
Oct 11, 2005·Journal of Cellular Biochemistry·Mary B GoldringKosei Ijiri
Dec 8, 2005·International Orthopaedics·H HiguchiK Takagishi
Apr 24, 2007·Osteoarthritis and Cartilage·A HennerbichlerF Guilak
May 29, 2007·Arthritis and Rheumatism·C T G AppletonF Beier
Feb 6, 2008·Journal of Immigrant and Minority Health·K C BrouwerS A Strathdee
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Jan 12, 2010·Osteoarthritis and Cartilage·C Ruiz-Romero, F J Blanco
Feb 18, 2010·Cell Host & Microbe·Anthony OrvedahlBeth Levine
Jul 1, 2010·The American Journal of Sports Medicine·Michael J SalataJon K Sekiya
Oct 5, 2010·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Vanessa G CuellarGaetano J Scuderi
Feb 19, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Megan Leigh KillianTammy Lynn Haut Donahue
Apr 27, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Donald D AndersonJoseph A Buckwalter
May 3, 2011·The Journal of Bone and Joint Surgery. American Volume·Sunny KimRichard Marder
Sep 5, 2012·Osteoarthritis and Cartilage·L ZhangG Gibson
Jul 19, 2013·The American Journal of Sports Medicine·Geoffrey D AbramsBrian J Cole
Aug 29, 2013·Cellular and Molecular Life Sciences : CMLS·Christian Ries
Oct 11, 2013·International Journal of Molecular Sciences·Jeng-Long HsiehPo-Chuan Shen
Dec 18, 2013·Clinical Orthopaedics and Related Research·Yu MatsukuraIchiro Sekiya
Jun 27, 2014·International Orthopaedics·Thomas MabeyPongsak Yuktanandana
Oct 23, 2014·The Journal of Knee Surgery·Brandon L RollerJames L Cook
May 25, 2015·Osteoarthritis and Cartilage·S RobertsJ H Kuiper

❮ Previous
Next ❯

Citations

Dec 4, 2019·BMC Musculoskeletal Disorders·Yi LongAishan He
Sep 30, 2020·Tissue Engineering. Part B, Reviews·Hao LiQuanyi Guo
Jan 24, 2021·Arthritis Research & Therapy·Nils RosshirtBabak Moradi
Dec 12, 2020·Osteoarthritis and Cartilage·L P LyonsA L McNulty
Aug 17, 2021·JBJS Reviews·Danielle H MarkusEric J Strauss
Nov 6, 2021·Arthritis Research & Therapy·Sophia Y Kim-WangAmy L McNulty

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

R
MSD Discover Workbench
lme4 R package
R Foundation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Vanessa Gabrovsky CuellarEric J Strauss
Archives of Orthopaedic and Trauma Surgery
Tetsuo HaginoHirotaka Haro
© 2022 Meta ULC. All rights reserved