Alterations in T-cell signal transduction molecules associated with recurrent spontaneous pregnancy loss

Journal of Reproductive Immunology
Douglas D Taylor, Cicek Gercel-Taylor

Abstract

Clinical evidence suggests that cell-mediated immunity is altered during pregnancy and that failure to suppress the maternal immune response can lead to placentation failure, resulting in partial or total rejection of the fetus. In contrast to women experiencing recurrent spontaneous abortions (RSA), normal uncomplicated pregnancies are associated decreased T-cell proliferation and production of Th1 cytokines and increased T-cell apoptosis. This study addresses a circulating factor in normal pregnancy that may mediate these events. Sera were obtained from three groups: pregnant women who have uncomplicated term deliveries (Group 1, n = 8), pregnant women with a history of RSA, who subsequently abort (Group 2, n = 10), and age-matched non-pregnant female controls (Group 3, n = 8). Pregnancy sera were obtained between 10 and 12 weeks of gestation. Using chromatography, a CD3-zeta inhibitory factor (or analogous fraction) was isolated from each patient within each group and incubated with cultured T-cells, Jurkat and HUT-78 cells. Apoptosis was assayed by a cell-death ELISA and IL-2 production by cytokine-specific ELISA. Apoptosis regulatory proteins and signaling molecules were analyzed by western immunoblotting. Group 1 material...Continue Reading

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Citations

Jun 22, 2010·American Journal of Reproductive Immunology : AJRI·Safinur AtayDouglas D Taylor
Jan 3, 2006·Gynecologic Oncology·Sibel AkyolDouglas D Taylor
Aug 23, 2005·Journal of Reproductive Immunology·Shin-Heng ChiouHo Hong-Nerng
Oct 26, 2007·Reproductive Sciences·Henry C BohlerDouglas D Taylor
May 4, 2006·Annual Review of Plant Biology·Dianna BowlesFabián E Vaistij
Nov 7, 2017·Experimental and Therapeutic Medicine·Shuqin XiaAiming Wang

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