Alterations in target cell membrane phospholipids alter T cell but not NK cell killing

Immunobiology
David T Harris

Abstract

The ability of tumor cells to grow progressively in vivo despite the host immune response remains a major conundrum in tumor immunology. Various mechanisms have been proposed to explain how tumors evade immune destruction. The work presented herein shows that simple alterations in plasma membrane phospholipid composition can alter susceptibility to immune lysis. The phospholipid composition of target cells was specifically altered by growth in medium containing choline analogs. Manipulation of membrane phospholipids was observed to alter cell susceptibility to murine CTL but not NK cell lysis. The effects of such changes in phospholipid composition on CTL-mediated lysis appeared to occur during the recognition phase of lysis. This mechanism could be a means by which tumor cells, as well as other pathogenic organisms, escape immune detection and destruction.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M ShinitzkyN Haran-Ghera
Oct 1, 1976·Science·P C Nowell
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M GlaserP R Vagelos
Apr 25, 1973·Nature: New Biology·G Berke, D B Amos
Jan 1, 1980·Scandinavian Journal of Infectious Diseases·P Koskela, E Herva
Oct 3, 2003·Journal of Cellular Biochemistry·Ellen AckerstaffZaver M Bhujwalla
Oct 19, 2005·Cancer Research·Egidio IorioFranca Podo

❮ Previous
Next ❯

Citations

Jun 20, 2015·Journal of Movement Disorders·Ruth H Walker
Oct 27, 2018·Molecular Medicine Reports·Xiang-Hua YuYa-Ling Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.