Abstract
Quaking mutants and jimpy mutants of mice have known deficiencies of myelination of the central nervous system, as well as lesser involvement of the peripheral nervous system. Both mutants also have altered polyamine synthesis and accumulation, particularly in the hindbrain and spinal column. The ratio of spermidine/spermine, which generally is higher in tissues with high rates of biosynthetic activity, was significantly lower in the mutants as compared to their normal siblings. In quaking mutants, 5 months of age, the spermidine concentration of hindbrain and spinal column was 60% that of controls. In contrast, the decreased spermidine/spermine ratio in jimpy mutants resulted from a marked increase in the spermine concentration in both forebrain and hindbrain. Alterations in the spermidine/spermine ratio could lead to reductions in the biosynthetic potential of the brain during development.
References
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Russell, S H Snyder
Dec 1, 1972·Experimental Neurology·H Meier, A D MacPike
Jan 1, 1974·Journal of Neurobiology·D H Russell, E Gfeller
Aug 1, 1972·The Biochemical Journal·D H Russell, J J Potyraj
Nov 1, 1972·The Biochemical Journal·D H Russell, T A McVicker
Feb 1, 1973·The Journal of Experimental Zoology·E M Eicher, P C Hoppe
Sep 1, 1973·Experimental Cell Research·B Westermark
May 16, 1974·Life Sciences·C A Manen, D H Russell
Jul 20, 1971·Biochimica Et Biophysica Acta·D H Russell, T A McVicker
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D H Russell
Jun 1, 1969·Journal of Neurochemistry·J L NussbaumP Mandel
Jan 8, 1971·Brain Research·B Berger
Jun 1, 1971·Endocrinology·D H Russell, R L Taylor
Apr 1, 1968·European Journal of Biochemistry·N A BaumannM L Harpin
Sep 1, 1968·The Biochemical Journal·A E Pegg, H G Williams-Ashman
Feb 1, 1969·Endocrinology·D H Russell, S H Snyder
Jan 1, 1964·Biochemical and Biophysical Research Communications·R G Ham
Feb 1, 1956·The Biochemical Journal·K BURTON
Apr 17, 1964·Science·R L SIDMANS H APPEL
Jul 23, 1965·Science·W G Dykstra, E J Herbst
Citations
Nov 26, 2011·Clinical Reviews in Allergy & Immunology·Wesley H Brooks
Sep 1, 1976·Life Sciences·J A SturmanT D Lindquist
Jan 1, 1981·Neurochemistry International·N Seiler
Dec 1, 1978·Neuroscience Letters·P P Giorgi
Nov 26, 2002·Medical Hypotheses·Wesley H Brooks
Dec 25, 2004·Medical Hypotheses·Wesley H Brooks
Jul 22, 1977·Brain Research·N A IngogliaR A Eisner
Mar 13, 2015·Frontiers in Genetics·Wesley H Brooks, Yves Renaudineau
Jun 1, 1977·Journal of Neurochemistry·P A McAnultyJ C Waterlow
Jan 1, 1979·Biochemical Pharmacology·G G Shaw
Apr 15, 1976·Life Sciences·J A Sturman