PMID: 9443096Jan 27, 1998Paper

Alterations in the carnitine metabolism in epileptic children treated with valproic acid

Journal of Korean Medical Science
S ChungC Bae

Abstract

Serum concentrations of total carnitine, free carnitine and acylcarnitine were measured in forty-one epileptic patients treated with valproic acid (VPA). Among them, 14 patients were on VPA monotherapy and 27 were on VPA polytherapy. Forty-one age and sex matched healthy normal controls were also evaluated for carnitine metabolism. The mean total and free carnitine were significantly lower in both the VPA monotherapy and polytherapy groups compared with the controls. However, there were no significant differences in concentrations of carnitine between the VPA polytherapy and VPA monotherapy groups. Patients treated with VPA polytherapy had lower carnitine than those treated with VPA monotherapy. An inverse correlation was found between serum concentrations of carnitine and duration of treatment in patients treated with VPA. However, there was no significant correlations between serum concentrations of carnitine and those of VPA. Also, correlation between serum concentrations of carnitine and the activities of serum GOT and GPT was not significant. After L-carnitine supplementation in eleven patients with hypocarnitinemia, the concentrations of carnitine were significantly increased.

Citations

Apr 21, 2017·The Journal of International Medical Research·Cecilia MaldonadoMarta Vázquez
Jan 27, 2009·Journal of Child Neurology·Murat AnilMustafa Dilek
Apr 11, 2001·Journal of Neurosurgical Anesthesiology·P N Varelas, M A Mirski
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists

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